Altered speeds and trajectories of neurons migrating in the ventricular and subventricular zones of the reeler neocortex

Britto, Joanne M., Tait, Karen J., Johnston, Leigh A., Hammond, Vicki E., Kalloniatis, Michael and Tan, Seong-Seng (2011) Altered speeds and trajectories of neurons migrating in the ventricular and subventricular zones of the reeler neocortex. Cerebral Cortex, 21 5: 1018-1027. doi:10.1093/cercor/bhq168


Author Britto, Joanne M.
Tait, Karen J.
Johnston, Leigh A.
Hammond, Vicki E.
Kalloniatis, Michael
Tan, Seong-Seng
Title Altered speeds and trajectories of neurons migrating in the ventricular and subventricular zones of the reeler neocortex
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
1460-2199
Publication date 2011
Year available 2011
Sub-type Article (original research)
DOI 10.1093/cercor/bhq168
Open Access Status
Volume 21
Issue 5
Start page 1018
End page 1027
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2011
Language eng
Abstract The Reelin signaling pathway is essential for proper cortical development, but it is unclear to whether Reelin function is primarily important for cortical layering or neuron migration. It has been proposed that Reelin is perhaps required only for somal translocation but not glial-dependent locomotion. This implies that the location of neurons responding to Reelin is restricted to the outer regions of the cortical plate (CP). To determine whether Reelin is required for migration outside of the CP, we used time-lapse imaging to track the behavior of cells undergoing locomotion in the germinal zones. We focused on the migratory activity in the ventricular/subventricular zones where the first transition of bipolar to multipolar migration occurs and where functional Reelin receptors are known to be expressed. Despite Reelin loss, neurons had no difficulty in undergoing radial migration and indeed displayed greater migratory speed. Additionally, compared with the wild-type, reeler neurons displayed altered trajectories with greater deviation from a radial path. These results suggest that Reelin loss has early consequences for migration in the germinal zones that are portrayed as defective radial trajectories and migratory speeds. Together, these abnormalities can give rise to the increased cell dispersion observed in the reeler cortex.
Keyword Bipolar
Cortex
Migration
Multipolar
Reelin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 27 Oct 2014, 17:11:55 EST by Sylvie Pichelin on behalf of Queensland Brain Institute