Using a panel of immunomarkers to define homologies in mammalian brains

Watson, Charles R., Paxinos, George and Tokuno, Hironebu (2010) Using a panel of immunomarkers to define homologies in mammalian brains. Frontiers in Human Neuroscience, 4 13.1-13.5. doi:10.3389/neuro.09.013.2010

Author Watson, Charles R.
Paxinos, George
Tokuno, Hironebu
Title Using a panel of immunomarkers to define homologies in mammalian brains
Journal name Frontiers in Human Neuroscience   Check publisher's open access policy
ISSN 1662-5161
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.3389/neuro.09.013.2010
Open Access Status DOI
Volume 4
Start page 13.1
End page 13.5
Total pages 5
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2010
Language eng
Subject 2738 Psychiatry and Mental health
2808 Neurology
2803 Biological Psychiatry
2802 Behavioral Neuroscience
3206 Neuropsychology and Physiological Psychology
Abstract Brain mapping has relied on a small number of routine chemical stains for many decades. The advent of immunomarkers has had a major impact on the ability to defi ne homologous nuclei from one species to another. The fi rst atlas to present a panel of immunomarkers was that of Paxinos et al. (1999a,b) in the adult rat brain. The markers used were parvalbumin, calbindin, calretinin, SMI32, tyrosine hydroxylase, and NADPH diaphorase (plus nissl and acetylcholinesterase). The 'signature' of a nucleus of interest in a new species can be tested against the findings in the rat. Since the pattern of immunomarkers seems to be conserved in mammalian evolution, such extrapolations can be made with reasonable confidence. A marmoset brain stained with a comprehensive set of immunomarkers has recently been published on the internet (Tokuno et al., 2009) and we are in the process of defining nuclear homologies in this brain by comparison with the same markers in the rat. In this article, we present an example (mapping the amygdale in the marmoset) which demonstrates the application of this immunomarker panel in defining homologies. The technique is particularly valuable in situations where little data on hodology or electrophysiology are available.
Keyword Amygdale
Brain mapping
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Created: Mon, 27 Oct 2014, 16:38:47 EST by Sylvie Pichelin on behalf of Queensland Brain Institute