Precerebellar cell groups in the hindbrain of the mouse defined by retrograde tracing and correlated with cumulative Wnt1-cre genetic labeling

Fu, YuHong, Tvrdik, Petr, Makki, Nadja, Paxinos, George and Watson, Charles (2011) Precerebellar cell groups in the hindbrain of the mouse defined by retrograde tracing and correlated with cumulative Wnt1-cre genetic labeling. Cerebellum, 10 3: 570-584. doi:10.1007/s12311-011-0266-1


Author Fu, YuHong
Tvrdik, Petr
Makki, Nadja
Paxinos, George
Watson, Charles
Title Precerebellar cell groups in the hindbrain of the mouse defined by retrograde tracing and correlated with cumulative Wnt1-cre genetic labeling
Journal name Cerebellum   Check publisher's open access policy
ISSN 1473-4222
Publication date 2011
Sub-type Article (original research)
DOI 10.1007/s12311-011-0266-1
Open Access Status
Volume 10
Issue 3
Start page 570
End page 584
Total pages 15
Place of publication New York, NY, United States
Publisher Springer
Subject 2808 Neurology
2728 Clinical Neurology
Abstract The precerebellar nuclei are hindbrain and spinal cord centers that send fibers to the cerebellum. The neurons of the major hindbrain precerebellar nuclei are derived from the rhombic lip. Wnt1, a developmentally important gene involved in intercellular signaling, is expressed in the developing rhombic lip. We sought to investigate the relationship between the cell clusters expressing Wnt1 and the precerebellar nuclei in the hindbrain. We therefore defined the hindbrain precerebellar nuclei by retrograde tracing, following cerebellar injections of HRP, and compared these results with the cell clusters expressing Wnt1 in newborn mice. We found that 39 distinct hindbrain nuclei project to the cerebellum. Of these nuclei, all but three (namely the oral pontine reticular nucleus, the caudal pontine reticular nucleus, and the subcoeruleus nucleus) contain neurons expressing Wnt1. This shows a high degree of overlap between the precerebellar nuclei and the nuclei that express Wnt1. However, it should be noted that neurons expressing Wnt1 are also found in the superior olivary complex, which is a basal plate derivative lacking cerebellar projections.
Keyword Hindbrain
Inferior olivary nucleus
Precerebellar nuclei
Rhombic lip
Wnt1
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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