The spinal precerebellar nuclei: calcium binding proteins and gene expression profile in the mouse

Fu, YuHong, Sengul, Gulgun, Paxinos, George and Watson, Charles (2012) The spinal precerebellar nuclei: calcium binding proteins and gene expression profile in the mouse. Neuroscience Letters, 518 2: 161-166. doi:10.1016/j.neulet.2012.05.002


Author Fu, YuHong
Sengul, Gulgun
Paxinos, George
Watson, Charles
Title The spinal precerebellar nuclei: calcium binding proteins and gene expression profile in the mouse
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
1872-7972
Publication date 2012-06-19
Sub-type Article (original research)
DOI 10.1016/j.neulet.2012.05.002
Open Access Status
Volume 518
Issue 2
Start page 161
End page 166
Total pages 6
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Subject 2800 Neuroscience
Abstract We have localized the spinocerebellar neuron groups in C57BL/6J mice by injecting the retrograde neuronal tracer Fluoro-Gold into the cerebellum and examined the distribution of SMI 32 and the calcium-binding proteins (CBPs), calbindin-D-28K (Cb), calretinin (Cr), and parvalbumin (Pv) in the spinal precerebellar nuclei. The spinal precerebellar neuron clusters identified were the dorsal nucleus, central cervical nucleus, lumbar border precerebellar nucleus, lumbar precerebellar nucleus, and sacral precerebellar nucleus. Some dispersed neurons in the deep dorsal horn and spinal laminae 6-8 also projected to the cerebellum. Cb, Cr, Pv, and SMI 32 were present in all major spinal precerebellar nuclei and Pv was the most commonly observed CBP. A number of genes expressed in hindbrain precerebellar nuclei are also expressed in spinal precerebellar groups, but there were some differences in gene expression profile between the different spinal precerebellar nuclei, pointing to functional diversity amongst them.
Keyword Calcium binding proteins
Genes
Precerebellar nucleus
SMI 32
Spinal cord
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 27 Oct 2014, 16:31:29 EST by Sylvie Pichelin on behalf of Queensland Brain Institute