A multidimensional magnetic resonance histology atlas of the Wistar rat brain

Johnson, G. Allan, Calabrese, Evan, Badea, Alexandra, Paxinos, George and Watson, Charles (2012) A multidimensional magnetic resonance histology atlas of the Wistar rat brain. NeuroImage, 62 3: 1848-1856. doi:10.1016/j.neuroimage.2012.05.041

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Author Johnson, G. Allan
Calabrese, Evan
Badea, Alexandra
Paxinos, George
Watson, Charles
Title A multidimensional magnetic resonance histology atlas of the Wistar rat brain
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2012-09
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2012.05.041
Open Access Status File (Author Post-print)
Volume 62
Issue 3
Start page 1848
End page 1856
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract We have produced a multidimensional atlas of the adult Wistar rat brain based on magnetic resonance histology (MRH). This MR atlas has been carefully aligned with the widely used Paxinos-Watson atlas based on optical sections to allow comparisons between histochemical and immuno-marker data, and the use of the Paxinos-Watson abbreviation set. Our MR atlas attempts to make a seamless connection with the advantageous features of the Paxinos-Watson atlas, and to extend the utility of the data through the unique capabilities of MR histology: a) ability to view the brain in the skull with limited distortion from shrinkage or sectioning; b) isotropic spatial resolution, which permits sectioning along any arbitrary axis without loss of detail; c) three-dimensional (3D) images preserving spatial relationships; and d) widely varied contrast dependent on the unique properties of water protons. 3D diffusion tensor images (DTI) at what we believe to be the highest resolution ever attained in the rat provide unique insight into white matter structures and connectivity. The 3D isotropic data allow registration of multiple data sets into a common reference space to provide average atlases not possible with conventional histology. The resulting multidimensional atlas that combines Paxinos-Watson with multidimensional MRH images from multiple specimens provides a new, comprehensive view of the neuroanatomy of the rat and offers a collaborative platform for future rat brain studies.
Keyword Atlas
Diffusion tensor imaging
Rat brain
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Created: Mon, 27 Oct 2014, 16:30:56 EST by Sylvie Pichelin on behalf of Queensland Brain Institute