Watson, Charles (2012). Hindbrain. In Charles Watson, George Paxinos and Luis Puelles (Ed.), The Mouse Nervous System (pp. 398-423) Austraila: Elsevier Inc.. doi:10.1016/B978-0-12-369497-3.10012-3

Author Watson, Charles
Title of chapter Hindbrain
Title of book The Mouse Nervous System
Place of Publication Austraila
Publisher Elsevier Inc.
Publication Year 2012
Sub-type Chapter in reference work, encyclopaedia, manual or handbook
DOI 10.1016/B978-0-12-369497-3.10012-3
Open Access Status
Year available 2012
ISBN 9780123694973
Editor Charles Watson
George Paxinos
Luis Puelles
Chapter number 12
Start page 398
End page 423
Total pages 26
Total chapters 33
Collection year 2012
Language eng
Formatted Abstract/Summary
The hindbrain is derived from the embryonic hindbrain vesicle. It is continuous rostrally with the midbrain and caudally with the spinal cord. The cerebellum is an outgrowth from the rostral hindbrain. Modern studies of gene expression reveal that the hindbrain is logically divided into 12 segmental components—the isthmus plus rhombomeres 1–11. The isthmus is a forgotten part of the mammalian brain. The isthmus is in fact the most rostral part of the hindbrain, not a caudal part of the mensencephalon. The isthmic region plays a crucial role in early development as a secondary organizing center, specifiying the fate of the area rostral to it (midbrain), and the area caudal (rhombencephalon and cerebellum). The isthmus of the mammalian brain is a distinct but relatively thin segment of the brain, separating the mesencephalon from the first rhombomere. The rhombomeres are transverse developmental units of the embryonic hindbrain. The rostral rhombomeres (r1–r6) are initially marked by transverse constrictions in the neural tube wall. The cerebellum is an outgrowth of the dorsal parts (the rhombic lip region) of the isthmus and rhombomere 1. The sensory nuclei of the hindbrain include somatosensory nuclei, auditory nuclei, vestibular nuclei, and the nuclei associated with visceral sensation. The primary nucleus receiving visceral sensation is the nucleus of the solitary tract. The hindbrain contains a number of distinctive monoamine nuclei that have important roles in controlling behavioral states and cardiovascular function. The major groups contain adrenergic, noradrenergic, dopaminergic, serotoninergic neurons. The hindbrain is a corridor between the forebrain and midbrain on one side and the spinal cord on the other.
Q-Index Code BX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
Collection: Queensland Brain Institute Publications
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Created: Mon, 27 Oct 2014, 16:23:25 EST by Sylvie Pichelin on behalf of Queensland Brain Institute