The interfascicular trigeminal nucleus: a precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping

Fu, Yuhong, Tvrdik, Petr, Makki, Nadja, Machold, Robert, Paxinos, George and Watson, Charles (2013) The interfascicular trigeminal nucleus: a precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping. Journal of Comparative Neurology, 521 3: 697-708. doi:10.1002/cne.23200

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Author Fu, Yuhong
Tvrdik, Petr
Makki, Nadja
Machold, Robert
Paxinos, George
Watson, Charles
Title The interfascicular trigeminal nucleus: a precerebellar nucleus in the mouse defined by retrograde neuronal tracing and genetic fate mapping
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
1096-9861
Publication date 2013-02-15
Sub-type Article (original research)
DOI 10.1002/cne.23200
Open Access Status File (Author Post-print)
Volume 521
Issue 3
Start page 697
End page 708
Total pages 12
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 2800 Neuroscience
Abstract We have found a previously unreported precerebellar nucleus located among the emerging fibers of the motor root of the trigeminal nerve in the mouse, which we have called the interfascicular trigeminal nucleus (IF5). This nucleus had previously been named the tensor tympani part of the motor trigeminal nucleus (5TT) in rodent brain atlases, because it was thought to be a subset of small motor neurons of the motor trigeminal nucleus innervating the tensor tympani muscle. However, following injection of retrograde tracer in the cerebellum, the labeled neurons in IF5 were found to be choline acetyltransferase (ChAT) negative, indicating that they are not motor neurons. The cells of IF5 are strongly labeled in mice from Wnt1Cre and Atoh1 CreER lineage fate mapping, in common with the major precerebellar nuclei that arise from the rhombic lip and that issue mossy fibers. Analysis of sections from mouse Hoxa3, Hoxb1, and Egr2 Cre labeled lineages shows that the neurons of IF5 arise from rhombomeres caudal to rhombomere 4, most likely from rhombomeres 6-8. We conclude that IF5 is a significant precerebellar nucleus in the mouse that shares developmental gene expression characteristics with mossy fiber precerebellar nuclei that arise from the caudal rhombic lip.
Keyword Motor trigeminal nucleus
Pontine nuclei
Principal sensory trigeminal nucleus
Rhombic lip
Tensor tympani
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Mon, 27 Oct 2014, 15:41:17 EST by Sylvie Pichelin on behalf of Queensland Brain Institute