The inferior olive of the C57BL/6J Mouse: A chemoarchitectonic study

Yu, You, Fu, Yuhong and Watson, Charles (2014) The inferior olive of the C57BL/6J Mouse: A chemoarchitectonic study. Anatomical Record, 297 2: 289-300. doi:10.1002/ar.22866

Author Yu, You
Fu, Yuhong
Watson, Charles
Title The inferior olive of the C57BL/6J Mouse: A chemoarchitectonic study
Journal name Anatomical Record   Check publisher's open access policy
ISSN 1932-8486
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1002/ar.22866
Open Access Status
Volume 297
Issue 2
Start page 289
End page 300
Total pages 12
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons Inc.
Collection year 2015
Language eng
Abstract We have used the histochemical and immunohistochemical staining methods and maps of gene expression to analyze the structure of the inferior olive of the C57BL mouse. As in other mammals, the inferior olive of the C57BL mouse contains three major nuclei, the medial nucleus, the principal nucleus, and the dorsal nucleus. The medial nucleus can be divided into a rostral medial nucleus and a more complex caudal part, which is formed by subnuclei C, B, A, the cap of Kooy, and the beta subnucleus. The principal nucleus includes the major principal nucleus and the arcuate subnucleus. Most of the inferior olive neurons are small to medium size, the smallest of which are found in the arcuate subnucleus. Calbindin and the vesicular glutamate transporter 2 gene are expressed in nearly all inferior olive neurons, but acetlycholinesterase, glutamate decarboxylase 1 gene, cocaine- and amphetamine-regulated transcript protein prepropeptide gene, galanin gene, and calretinin are selectively expressed within different subnuclei. These findings are consistent with a pattern of extensive functional differentiation among the neuron groups of the inferior olive.
Keyword Cerebellum
Inferior olive
Purkinje cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
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Created: Mon, 27 Oct 2014, 15:21:58 EST by Sylvie Pichelin on behalf of Queensland Brain Institute