Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Hysi, Pirro G., Cheng, Ching-Yu, Springelkamp, Henriet, Macgregor, Stuart, Bailey, Jessica N. Cooke, Wojciechowski, Robert, Vitart, Veronique, Nag, Abhishek, Hewitt, Alex W., Hohn, Rene, Venturini, Cristina, Mirshahi, Alireza, Ramdas, Wishal D., Thorleifsson, Gudmar, Vithana, Eranga, Khor, Chiea-Chuen, Stefansson, Arni B., Liao, Jiemin, Haines, Jonathan L., Amin, Najaf, Wang, Ya Xing, Wild, Philipp S., Ozel, Ayse B., Li, Jun Z., Fleck, Brian W., Zeller, Tanja, Staffieri, Sandra E., Teo, Yik-Ying, Cuellar-Partida, Gabriel, Luo, Xiaoyan, Allingham, R. Rand, Richards, Julia E., Senft, Andrea, Karssen, Lennart C., Zheng, Yingfeng, Bellenguez, Celine, Xu, Liang, Iglesias, Adriana I., Wilson, James F., Kang, Jae H., van Leeuwen, Elisabeth M., Jonsson, Vesteinn, Thorsteinsdottir, Unnur, Despriet, Dominiek D. G., Ennis, Sarah, Moroi, Sayoko E., Martin, Nicholas G., Jansonius, Nomdo M., Yazar, Seyhan, Tai, E-Shyong, Amouyel, Philippe, Kirwan, James, van Koolwijk, Leonieke M. E., Hauser, Michael A., Jonasson, Fridbert, Leo, Paul, Loomis, Stephanie J., Fogarty, Rhys, Rivadeneira, Fernando, Kearns, Lisa, Lackner, Karl J., de Jong, Paulus T. V. M., Simpson, Claire L., Pennell, Craig E., Oostra, Ben A., Uitterlinden, Andre G., Saw, Seang-Mei, Lotery, Andrew J., Bailey-Wilson, Joan E., Hofman, Albert, Vingerling, Johannes R., Maubaret, Cecilia, Pfeiffer, Norbert, Wolfs, Roger C. W., Lemij, Hans G., Young, Terri L., Pasquale, Louis R., Delcourt, Cecile, Spector, Timothy D., Klaver, Caroline C. W., Small, Kerrin S., Burdon, Kathryn P., Stefansson, Kari, Wong, Tien-Yin, Viswanathan, Ananth, Mackey, David A., Craig, Jamie E., Wiggs, Janey L., van Duijn, Cornelia M., Hammond, Christopher J. and Aung, Tin (2014) Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. Nature Genetics, 46 10: 1126-1130. doi:10.1038/ng.3087


Author Hysi, Pirro G.
Cheng, Ching-Yu
Springelkamp, Henriet
Macgregor, Stuart
Bailey, Jessica N. Cooke
Wojciechowski, Robert
Vitart, Veronique
Nag, Abhishek
Hewitt, Alex W.
Hohn, Rene
Venturini, Cristina
Mirshahi, Alireza
Ramdas, Wishal D.
Thorleifsson, Gudmar
Vithana, Eranga
Khor, Chiea-Chuen
Stefansson, Arni B.
Liao, Jiemin
Haines, Jonathan L.
Amin, Najaf
Wang, Ya Xing
Wild, Philipp S.
Ozel, Ayse B.
Li, Jun Z.
Fleck, Brian W.
Zeller, Tanja
Staffieri, Sandra E.
Teo, Yik-Ying
Cuellar-Partida, Gabriel
Luo, Xiaoyan
Allingham, R. Rand
Richards, Julia E.
Senft, Andrea
Karssen, Lennart C.
Zheng, Yingfeng
Bellenguez, Celine
Xu, Liang
Iglesias, Adriana I.
Wilson, James F.
Kang, Jae H.
van Leeuwen, Elisabeth M.
Jonsson, Vesteinn
Thorsteinsdottir, Unnur
Despriet, Dominiek D. G.
Ennis, Sarah
Moroi, Sayoko E.
Martin, Nicholas G.
Jansonius, Nomdo M.
Yazar, Seyhan
Tai, E-Shyong
Amouyel, Philippe
Kirwan, James
van Koolwijk, Leonieke M. E.
Hauser, Michael A.
Jonasson, Fridbert
Leo, Paul
Loomis, Stephanie J.
Fogarty, Rhys
Rivadeneira, Fernando
Kearns, Lisa
Lackner, Karl J.
de Jong, Paulus T. V. M.
Simpson, Claire L.
Pennell, Craig E.
Oostra, Ben A.
Uitterlinden, Andre G.
Saw, Seang-Mei
Lotery, Andrew J.
Bailey-Wilson, Joan E.
Hofman, Albert
Vingerling, Johannes R.
Maubaret, Cecilia
Pfeiffer, Norbert
Wolfs, Roger C. W.
Lemij, Hans G.
Young, Terri L.
Pasquale, Louis R.
Delcourt, Cecile
Spector, Timothy D.
Klaver, Caroline C. W.
Small, Kerrin S.
Burdon, Kathryn P.
Stefansson, Kari
Wong, Tien-Yin
Viswanathan, Ananth
Mackey, David A.
Craig, Jamie E.
Wiggs, Janey L.
van Duijn, Cornelia M.
Hammond, Christopher J.
Aung, Tin
Title Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2014-10
Year available 2014
Sub-type Article (original research)
DOI 10.1038/ng.3087
Open Access Status Not Open Access
Volume 46
Issue 10
Start page 1126
End page 1130
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing
Collection year 2015
Language eng
Abstract Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10−8 for rs6445055), two on chromosome 9 (P = 2.80 × 10−11 for rs2472493 near ABCA1 and P = 6.39 × 10−11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10−11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG.
Keyword Open-Angle Glaucoma
Central Corneal Thickness
Common Variants
Association
Metaanalysis
Population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
 
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