Gene expression studies in major depression

Mehta, Divya, Menke, Andreas and Binder, Elisabeth B. (2010) Gene expression studies in major depression. Current Psychiatry Reports, 12 2: 135-144. doi:10.1007/s11920-010-0100-3


Author Mehta, Divya
Menke, Andreas
Binder, Elisabeth B.
Title Gene expression studies in major depression
Journal name Current Psychiatry Reports   Check publisher's open access policy
ISSN 1523-3812
1535-1645
Publication date 2010
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11920-010-0100-3
Open Access Status
Volume 12
Issue 2
Start page 135
End page 144
Total pages 10
Place of publication Philadelphia, PA United States
Publisher Springer Healthcare
Collection year 2010
Language eng
Subject 2738 Psychiatry and Mental health
Abstract The dramatic technical advances in methods to measure gene expression on a genome-wide level thus far have not been paralleled by breakthrough discoveries in psychiatric disorders-including major depression (MD)- using these hypothesis-free approaches. In this review, we first describe the methodologic advances made in gene expression analysis, from quantitative polymerase chain reaction to nextgeneration sequencing. We then discuss issues in gene expression experiments specific to MD, ranging from the choice of target tissues to the characterization of the case group. We provide a synopsis of the gene expression studies published thus far for MD, with a focus on studies using mRNA microarray methods. Finally, we discuss possible new strategies for the gene expression studies in MD that circumvent some of the addressed issues.
Keyword Gene expression
Major depression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
 
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Created: Fri, 24 Oct 2014, 17:23:58 EST by Sylvie Pichelin on behalf of Queensland Brain Institute