Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples

Marioni, Riccardo E., Deary, Ian J., Murray, Gordon D., Lowe, Gordon D. O., Rafnsson, Snorri B., Strachan, Mark W. J., Luciano, Michelle, Houlihan, Lorna M., Gow, Alan J., Harris, Sarah E., Stewart, Marlene C., Rumley, Ann, Fowkes, F. Gerry R. and Price, Jackie F. (2010) Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples. Behavior Genetics, 40 1: 3-11. doi:10.1007/s10519-009-9302-z


Author Marioni, Riccardo E.
Deary, Ian J.
Murray, Gordon D.
Lowe, Gordon D. O.
Rafnsson, Snorri B.
Strachan, Mark W. J.
Luciano, Michelle
Houlihan, Lorna M.
Gow, Alan J.
Harris, Sarah E.
Stewart, Marlene C.
Rumley, Ann
Fowkes, F. Gerry R.
Price, Jackie F.
Title Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2010
Sub-type Article (original research)
DOI 10.1007/s10519-009-9302-z
Open Access Status
Volume 40
Issue 1
Start page 3
End page 11
Total pages 9
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract It is unknown whether the relationship between raised inflammatory biomarker levels and late-life cognitive ability is causal. We explored this issue by testing the association between genetic regulators of plasma C-reactive protein (CRP) and cognition. Data were analysed from four cohorts based in central Scotland (Total N = 4,782). Associations were tested between variants in the CRP gene and both plasma CRP levels and a battery of neuropsychological tests, including a vocabulary-based estimate of peak prior cognitive ability and a general (summary) cognitive factor score, or 'g'. CRP levels were associated with a number of variants in the CRP gene (SNPs), including rs1205, rs1130864, rs1800947, and rs1417938 (P range 4.2e-06 to 0.041). Higher CRP levels were also associated with vocabulary-adjusted cognitive ability, used here to estimate lifetime cognitive change (P range 1.7e-04 to 0.038). After correction for multiple testing and adjustment for age and sex, no statistically significant associations were found between the SNPs and cognition. CRP is unlikely to be a causal determinant of late-life cognitive ability.
Keyword C-reactive protein
Cognition
Cognitive decline
Inflammation
Single nucleotide Polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Fri, 24 Oct 2014, 12:43:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute