Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function

Bolton, Jennifer L., Marioni, Riccardo E., Deary, Ian J., Harris, Sarah E., Stewart, Marlene C., Murray, Gordon D., Fowkes, F. Gerry R. and Price, Jackie F. (2010) Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function. Behavior Genetics, 40 5: 630-638. doi:10.1007/s10519-010-9372-y


Author Bolton, Jennifer L.
Marioni, Riccardo E.
Deary, Ian J.
Harris, Sarah E.
Stewart, Marlene C.
Murray, Gordon D.
Fowkes, F. Gerry R.
Price, Jackie F.
Title Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
1573-3297
Publication date 2010
Sub-type Article (original research)
DOI 10.1007/s10519-010-9372-y
Open Access Status
Volume 40
Issue 5
Start page 630
End page 638
Total pages 9
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract The dopaminergic neurotransmitter system of the brain is involved in working memory and other cognitive functions. Studies suggest an important role for dopamine synthesis and uptake in modulation of human cognitive processes. We studied the association between polymorphisms in the catechol-o-methyl transferase (COMT) and dopamine receptor D2 (DRD2) genes and general cognitive ability in a secondary analysis of 2091 men and women, aged 55-80 years living in Scotland. General cognitive ability 'g' was derived from five cognitive tests of different domains. COMT was not associated with cognitive ability in this population. The DRD2 C:C genotype of rs6277 was associated with decreased general cognitive ability 'g' (p = 0.003), and DRD2 rs1800497 heterozygotes had lowest mean general cognitive ability 'g' (p = 0.007). There was an indication of a potential interaction between the DRD2 SNPs.
Keyword Cognition
COMT
Dopamine
DRD2
Genetic
Polymorphisms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Fri, 24 Oct 2014, 12:26:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute