Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts

Marioni, Riccardo E., Deary, Ian J., Murray, Gordon D., Lowe, Gordon D. O., Strachan, Mark W. J., Luciano, Michelle, Houlihan, Lorna M., Gow, Alan J., Harris, Sarah E., Rumley, Ann, Stewart, Marlene C., Fowkes, F. Gerry R. and Price, Jackie F. (2011) Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts. Behavior Genetics, 41 5: 691-699. doi:10.1007/s10519-011-9449-2

Author Marioni, Riccardo E.
Deary, Ian J.
Murray, Gordon D.
Lowe, Gordon D. O.
Strachan, Mark W. J.
Luciano, Michelle
Houlihan, Lorna M.
Gow, Alan J.
Harris, Sarah E.
Rumley, Ann
Stewart, Marlene C.
Fowkes, F. Gerry R.
Price, Jackie F.
Title Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts
Journal name Behavior Genetics   Check publisher's open access policy
ISSN 0001-8244
Publication date 2011-09
Sub-type Article (original research)
DOI 10.1007/s10519-011-9449-2
Open Access Status
Volume 41
Issue 5
Start page 691
End page 699
Total pages 9
Place of publication New York, NY, United States
Publisher Springer
Language eng
Abstract There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance. This study tested the association of single nucleotide polymorphisms in the fibrinogen α (FGA) and bβ (FGB) genes with cognitive performance. Data were analysed from three communitydwelling populations of older persons (>50 years) in central Scotland: the Aspirin for Asymptomatic Atherosclerosis (AAA) Trial (n = 2,091), the Edinburgh Type 2 Diabetes Study (ET2DS, n = 1,066), and the Lothian Birth Cohort 1936 (LBC1936, n = 1,091). Cognition was assessed using a battery of five, seven, and four psychometric tests, respectively. This information was used to derive a general cognitive factor. Weakly significant associations were found between the rs4220 (FGB), and rs2227412 (FGB) SNPs and a single test of cognitive performance in the AAA Trial (p\0.05). These findings did not replicate in the LBC1936 or ET2DS cohorts, except for the rs2227412 SNP, which was significantly associated with the general cognitive factor in the ET2DS (p = 3.3 9 10- 4). A summary term that combined results from all three studies suggested that the rs2227412 genotype associated with reduced cognitive ability also associated with higher plasma fibrinogen levels. These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons.
Keyword Ageing
Single nucleotide polymorphism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 24 Oct 2014, 12:18:31 EST by Debra McMurtrie on behalf of Queensland Brain Institute