Cognitive function, dementia and type 2 diabetes mellitus in the elderly

Strachan, Mark W. J., Reynolds, Rebecca M., Marioni, Riccardo E. and Price, Jacqueline F. (2011) Cognitive function, dementia and type 2 diabetes mellitus in the elderly. Nature Reviews Endocrinology, 7 2: 108-114. doi:10.1038/nrendo.2010.228

Author Strachan, Mark W. J.
Reynolds, Rebecca M.
Marioni, Riccardo E.
Price, Jacqueline F.
Title Cognitive function, dementia and type 2 diabetes mellitus in the elderly
Journal name Nature Reviews Endocrinology   Check publisher's open access policy
ISSN 1759-5029
Publication date 2011
Sub-type Article (original research)
DOI 10.1038/nrendo.2010.228
Open Access Status
Volume 7
Issue 2
Start page 108
End page 114
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Increasing numbers of people are developing type 2 diabetes mellitus, but interventions to prevent and treat the classic microvascular and macrovascular complications have improved, so that people are living longer with the condition. This trend means that novel complications of type 2 diabetes mellitus, which are not targeted by current management strategies, could start to emerge. Cognitive impairment and dementia could come into this category. Type 2 diabetes mellitus is associated with a 1.5-2.5-fold increased risk of dementia. The etiology of dementia and cognitive impairment in people with type 2 diabetes mellitus is probably multifactorial. Chronic hyperglycemia is implicated, perhaps by promoting the development of cerebral microvascular disease. Data suggest that the brains of older people with type 2 diabetes mellitus might be vulnerable to the effects of recurrent, severe hypoglycemia. Other possible moderators of cognitive function include inflammatory mediators, rheological factors and dysregulation of the hypothalamic-pituitary-adrenal axis. Cognitive function should now be included as a standard end point in randomized trials of therapeutic interventions in patients with type 2 diabetes mellitus.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 109 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 24 Oct 2014, 11:57:29 EST by Debra McMurtrie on behalf of Queensland Brain Institute