Association study of candidate variants of COMT with neuroticism, anxiety and depression

Wray, Naomi, James, Michael R., Dumenil, Troy, Handoko, Herlina Y., Lind, Penelope A., Montgomery, Grant W. and Martin, Nicholas G. (2008) Association study of candidate variants of COMT with neuroticism, anxiety and depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B 7: 1314-1318. doi:10.1002/ajmg.b.30744

Author Wray, Naomi
James, Michael R.
Dumenil, Troy
Handoko, Herlina Y.
Lind, Penelope A.
Montgomery, Grant W.
Martin, Nicholas G.
Title Association study of candidate variants of COMT with neuroticism, anxiety and depression
Journal name American Journal of Medical Genetics Part B: Neuropsychiatric Genetics   Check publisher's open access policy
ISSN 1552-4841
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1002/ajmg.b.30744
Open Access Status
Volume 147B
Issue 7
Start page 1314
End page 1318
Total pages 5
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons Inc.
Collection year 2008
Language eng
Formatted abstract
The Val158Met polymorphism of the gene encoding catechol-O- methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. In this study we investigate the association between three SNPs from COMT and anxiety and depression disorders and neuroticism all measured within the same study sample. Participants were selected as sibling pairs (or multiples) that were either concordant or discordant for extreme neuroticism scores from a total sample of 18,742 Australian twin individuals and their siblings. All participants completed the Composite International Diagnostic Interview (CIDI) from which diagnoses of DSM-IV depression and anxiety disorders were determined. Of the participants, 674 had a diagnosis of anxiety and/or depression from 492 families. Study participants (n = 2,045 from 987 families) plus, where possible, their parents were genotyped for rs737865, rs4680 (Val158Met), and rs165599. Using family based tests we looked for association between these variants and neuroticism, depression, anxiety, panic disorder and agarophobia (PDAG) and obsessive compulsive disorder. We found no convincing evidence for association either in allelic or genotypic tests for the total sample or when the sample was stratified by sex. Haplotype T-G-G showed weak association (P = 0.042) with PDAG before correction for multiple testing; association between this haplotype and schizophrenia has been previously reported in an Australian sample.
Keyword Anxiety
Major depression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes For ERA

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 23 Oct 2014, 17:25:02 EST by Debra McMurtrie on behalf of Queensland Brain Institute