Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans

Mangold, J. E., Payne, T. J., Ma, J. Z., Chen, G. and Li, M. D. (2008) Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. Journal of Medical Genetics, 45 9: 578-582. doi:10.1136/jmg.2008.057844


Author Mangold, J. E.
Payne, T. J.
Ma, J. Z.
Chen, G.
Li, M. D.
Title Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans
Journal name Journal of Medical Genetics   Check publisher's open access policy
ISSN 0022-2593
1468-6244
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1136/jmg.2008.057844
Open Access Status
Volume 45
Issue 9
Start page 578
End page 582
Total pages 5
Place of publication London United Kingdom
Publisher B M J Group
Language eng
Subject 1311 Genetics
2716 Genetics (clinical)
Formatted abstract
Context: Bitter sensitivity varies among individuals and ethnic groups partly due to polymorphisms in taste receptor genes (TAS2Rs). Although previous psychophysical studies suggest that taste status plays a role in nicotine dependence (ND), genetic evidence is lacking.

Objectives: To determine whether single nucleotide polymorphisms (SNPs) in TAS2R16 and TAS2R38 are associated with ND and if the effects differ by sex and ethnicity.

Design, setting, and participants: 2037 individuals from 602 nuclear families of African American (AA) or European American (EA) origin were recruited from the US mid-south states during 1999–2004.

Main outcome measures:
ND was assessed by three measures: indexed Smoking Quantity (SQ), Heaviness of Smoking Index (HSI), and the Fagerström Test for Nicotine Dependence (FTND). Peripheral blood samples were obtained for DNA extraction and genotyping.

Results: The TAS2R38 taster haplotype PAV was inversely associated (p = 0.0165), and the non-taster haplotype AVI was positively associated (p = 0.0120), with SQ in AA smokers. The non-taster haplotype was positively associated with all ND measures in AA female smokers (p = 0.01∼0.003). No significant associations were observed in the EA sample.

Conclusions: TAS2R38 polymorphisms are an important factor in determining ND in AAs. Heightened oral sensitivity confers protection against ND. Conversely, decreased sensitivity represents a risk factor for ND, especially in AA females. Together, our findings suggest that taster status plays a role in governing the development of ND and may represent a way to identify individuals at risk for developing ND, particularly in AA smokers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Thu, 23 Oct 2014, 10:56:05 EST by Ms Kate Rowe on behalf of Queensland Brain Institute