Association of amyloid precursor protein-­binding protein, family B, member 1 with nicotine dependence in African and European American smokers

Chen, Guo-Bo, Payne, Thomas J., Lou, Xiang-Yang, Ma, Jennie Z., Zhu, Jun and Li, Ming D. (2008) Association of amyloid precursor protein-­binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Human Genetics, 124 4: 393-398. doi:10.1007/s00439-008-0558-9


Author Chen, Guo-Bo
Payne, Thomas J.
Lou, Xiang-Yang
Ma, Jennie Z.
Zhu, Jun
Li, Ming D.
Title Association of amyloid precursor protein-­binding protein, family B, member 1 with nicotine dependence in African and European American smokers
Journal name Human Genetics   Check publisher's open access policy
ISSN 0340-6717
1432-1203
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1007/s00439-008-0558-9
Open Access Status
Volume 124
Issue 4
Start page 393
End page 398
Total pages 6
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2008
Language eng
Formatted abstract
Although epidemiological studies reveal that cigarette smoking is inversely associated with Alzheimer's disease (AD) and Parkinson's disease (PD), the underlying mechanism remains largely unknown. Considering the facts that amyloid precursor protein-binding protein, family B, member 1 (APBB1) is mapped to a suggestive linkage region on chromosome 11 for nicotine dependence (ND), and has been implicated in the pathogenesis of AD and PD, it represents a plausible candidate for genetic study of ND. Five single nucleotide polymorphisms (SNPs) within APBB1 were genotyped in a sample consisting of 2,037 participants of either African-American (AA) or European-American (EA) origin, and examined their associations with ND assessed by three commonly used measures: Smoking Quantity (SQ), the Heaviness of Smoking Index (HSI), and the Fagerström Test for ND (FTND). Individual SNP-based association analysis showed that all five SNPs are associated with at least one ND measure in one of the three samples; however, only the association of SNP rs4758416 with SQ and HSI remained significant after correction for multiple testing in the pooled sample. Haplotype analysis demonstrated three major haplotypes significantly associated with ND after Bonferroni correction. Formed by rs4758416-rs10839562-rs1079199, haplotype C-C-T showed positive association with FTND in the AA and pooled samples, and conversely, haplotype G-C-T showed negative association with SQ and HSI in AA and EA samples. Another haplotype, C-T-G, formed by rs10839562-rs1079199-rs8164, was significantly associated with HSI in the EA sample. Based on these findings, we conclude that APBB1 represents an important candidate gene in the genetic study on ND and neurodegenerative diseases and warrants further investigation in future.
Keyword Onset Alzheimers disease
Receptor related protein
Susceptibility Loci
Linkage analysis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes For ERA

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Thu, 23 Oct 2014, 10:48:51 EST by Debra McMurtrie on behalf of Queensland Brain Institute