Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta

Patel, J., Shafiee, A., Wang, W., Fisk, N. M. and Khosrotehrani, K. (2014) Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta. Placenta, 35 11: 969-971. doi:10.1016/j.placenta.2014.09.001


Author Patel, J.
Shafiee, A.
Wang, W.
Fisk, N. M.
Khosrotehrani, K.
Title Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2014
Sub-type Article (original research)
DOI 10.1016/j.placenta.2014.09.001
Volume 35
Issue 11
Start page 969
End page 971
Total pages 3
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Abstract The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34−, increasing evidence suggests that fetal MSC may be CD34 positive in vivo. We flow sorted term placental digests based on CD34+ expression and exploited differential culture media to isolate separately pure fetal and maternal MSC populations. This method has considerable translational implications, in particular to clinical trials underway with “placental” MSC of uncertain or decidual origin.
Keyword Mesenchymal stem cells
Fetal
Maternal
Placenta
Chorion
Decidua
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 22 Oct 2014, 10:19:14 EST by Professor Nicholas Fisk on behalf of Faculty of Medicine