Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy

Keizer, M. P., Wouters, D., Schlapbach, L. J. and Kuijpers, T. W. (2014) Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy. Molecular Immunology, 61 2: 174-184. doi:10.1016/j.molimm.2014.06.005


Author Keizer, M. P.
Wouters, D.
Schlapbach, L. J.
Kuijpers, T. W.
Title Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
1872-9142
Publication date 2014-10
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molimm.2014.06.005
Open Access Status
Volume 61
Issue 2
Start page 174
End page 184
Total pages 11
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2015
Language eng
Subject 1312 Molecular Biology
2403 Immunology
Abstract MBL-deficiency is a commonly occurring deficiency of the innate immune system, affecting a substantial part of the population and has been extensively studied. MBL appears to function as a disease modifier. The role of MBL in different conditions is context-dependent. Many clinical studies show conflicting results, which can be partially explained by different definitions of MBL-deficiency, including phenotype- and genotype-based approaches. In this review we give an overview of literature of MBL, its role in different pathologies, diseases and patient populations. We review MBL replacement studies, and discuss the potential of MBL substitution therapy. We finally suggest that new MBL substitution trials should be conducted within a predefined patient population. MBL-deficiency should be based on serum levels and confirmed by genotyping.
Keyword MBL-deficiency
MBL-genotype
MBL replacement therapy
Lectin pathway
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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