The critical role of the pathologist in determining eligibility for active surveillance as a management option in patients with prostate cancer: consensus statement with recommendations supported by the College of American Pathologists, International Soci

Amin, Mahul B., Lin, Daniel W., Gore, John L., Srigley, John R., Samaratunga, Hema, Egevad, Lars, Rubin, Mark, Nacey, John, Carter, H. Ballentine, Klotz, Laurence, Sandler, Howard, Zietman, Anthony L., Holden, Stuart, Montironi, Rodolfo, Humphrey, Peter A., Evans, Andrew J., Epstein, Jonathan I., Delahunt, Brett, McKenney, Jesse K., Berney, Dan, Wheeler, Thomas M., Chinnaiyan, Arul M., True, Lawrence, Knudsen, Beatrice and Hammond, M. Elizabeth H. (2014) The critical role of the pathologist in determining eligibility for active surveillance as a management option in patients with prostate cancer: consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation. Archives of Pathology and Laboratory Medicine, 138 10: 1387-1405. doi:10.5858/arpa.2014-0219-SA


Author Amin, Mahul B.
Lin, Daniel W.
Gore, John L.
Srigley, John R.
Samaratunga, Hema
Egevad, Lars
Rubin, Mark
Nacey, John
Carter, H. Ballentine
Klotz, Laurence
Sandler, Howard
Zietman, Anthony L.
Holden, Stuart
Montironi, Rodolfo
Humphrey, Peter A.
Evans, Andrew J.
Epstein, Jonathan I.
Delahunt, Brett
McKenney, Jesse K.
Berney, Dan
Wheeler, Thomas M.
Chinnaiyan, Arul M.
True, Lawrence
Knudsen, Beatrice
Hammond, M. Elizabeth H.
Title The critical role of the pathologist in determining eligibility for active surveillance as a management option in patients with prostate cancer: consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation
Journal name Archives of Pathology and Laboratory Medicine   Check publisher's open access policy
ISSN 0003-9985
1543-2165
Publication date 2014-10-01
Sub-type Article (original research)
DOI 10.5858/arpa.2014-0219-SA
Open Access Status
Volume 138
Issue 10
Start page 1387
End page 1405
Total pages 19
Place of publication Northfield, IL, United States
Publisher College of American Pathologists
Collection year 2015
Language eng
Formatted abstract
Context.—Prostate cancer remains a significant public health problem. Recent publications of randomized trials and the US Preventive Services Task Force recommendations have drawn attention to overtreatment of localized, low-risk prostate cancer. Active surveillance, in which patients undergo regular visits with serum prostate-specific antigen tests and repeat prostate biopsies, rather than aggressive treatment with curative intent, may address overtreatment of low-risk prostate cancer. It is apparent that a greater awareness of the critical role of pathologists in determining eligibility for active surveillance is needed.

Objectives.—To review the state of current knowledge about the role of active surveillance in the management of prostate cancer and to provide a multidisciplinary report focusing on pathologic parameters important to the successful identification of patients likely to succeed with active surveillance, to determine the role of molecular tests in increasing the safety of active surveillance, and to provide future directions.

Design.—Systematic review of literature on active surveillance for low-risk prostate cancer, pathologic parameters important for appropriate stratification, and issues regarding interobserver reproducibility. Expert panels were created to delineate the fundamental questions confronting the clinical and pathologic aspects of management of men on active surveillance.

Results.—Expert panelists identified pathologic parameters important for management and the related diagnostic and reporting issues. Consensus recommendations were generated where appropriate.

Conclusions.—Active surveillance is an important management option for men with low-risk prostate cancer. Vital to this process is the critical role pathologic parameters have in identifying appropriate candidates for active surveillance. These findings need to be reproducible and consistently reported by surgical pathologists with accurate pathology reporting.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Created: Tue, 21 Oct 2014, 03:19:43 EST by System User on behalf of Discipline of Molecular and Cellular Pathology