Feasibility of parental collected nasal swabs for virus detection in young children with cystic fibrosis

Gangell, C. L., Shackleton, C., Poreddy, S., Kappers, J., Gaydon, J. E., Sloots, T. P., Stick, S. M., Ranganathan, S. C. and Sly, P. D. (2014) Feasibility of parental collected nasal swabs for virus detection in young children with cystic fibrosis. Journal of Cystic Fibrosis, 13 6: 661-666. doi:10.1016/j.jcf.2014.02.009


Author Gangell, C. L.
Shackleton, C.
Poreddy, S.
Kappers, J.
Gaydon, J. E.
Sloots, T. P.
Stick, S. M.
Ranganathan, S. C.
Sly, P. D.
Title Feasibility of parental collected nasal swabs for virus detection in young children with cystic fibrosis
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
ISSN 1569-1993
1873-5010
Publication date 2014-03-15
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jcf.2014.02.009
Open Access Status
Volume 13
Issue 6
Start page 661
End page 666
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract Background: The detrimental role of viruses has been well described in CF, although the pattern of virus infections has not been investigated in a longitudinal study. The primary aim was to determine the feasibility of fortnightly parent collected swabs in young children with CF. Methods: Children under three years with CF were recruited. Nasal swabs were collected by parents every fortnight and during periods of symptoms over 12 months. Nasal swabs were posted and virus detected using real-time PCR. Results: Only 27% of the patients completed the study to 10 months, although 98% of the swabs returned were adequate for analysis. Mould was observed growing on 23% of the returned swabs. There was no evidence to demonstrate relationships with symptoms and viruses, prolonged symptoms, prolonged shedding or patterns of virus infections. Conclusions: This study highlights the need to further investigate the role of viruses in children with CF using a robust method of frequent collection in children for a longitudinal study, with appropriate storage and shipping techniques to avoid mould growth or other potential contaminants.
Keyword Virus
Cystic fibrosis
Paediatric
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online ahead of print 15 March 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Queensland Children's Medical Research Institute Publications
 
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