Physiological control of dual rotary pumps as a biventricular assist device using a master/slave approach

Stevens, Michael C., Wilson, Stephen, Bradley, Andrew, Fraser, John and Timms, Daniel (2014) Physiological control of dual rotary pumps as a biventricular assist device using a master/slave approach. Artificial Organs, 38 9: 766-774. doi:10.1111/aor.12303

Author Stevens, Michael C.
Wilson, Stephen
Bradley, Andrew
Fraser, John
Timms, Daniel
Title Physiological control of dual rotary pumps as a biventricular assist device using a master/slave approach
Journal name Artificial Organs   Check publisher's open access policy
ISSN 0160-564X
Publication date 2014-09
Year available 2014
Sub-type Article (original research)
DOI 10.1111/aor.12303
Open Access Status
Volume 38
Issue 9
Start page 766
End page 774
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2015
Language eng
Abstract Dual rotary left ventricular assist devices (LVADs) can provide biventricular mechanical support during heart failure. Coordination of left and right pump speeds is critical not only to avoid ventricular suction and to match cardiac output with demand, but also to ensure balanced systemic and pulmonary circulatory volumes. Physiological control systems for dual LVADs must meet these objectives across a variety of clinical scenarios by automatically adjusting left and right pump speeds to avoid catastrophic physiological consequences. In this study we evaluate a novel master/slave physiological control system for dual LVADs. The master controller is a Starling-like controller, which sets flow rate as a function of end-diastolic ventricular pressure (EDP). The slave controller then maintains a linear relationship between right and left EDPs. Both left/right and right/left master/slave combinations were evaluated by subjecting them to four clinical scenarios (rest, postural change, Valsalva maneuver, and exercise) simulated in a mock circulation loop. The controller's performance was compared to constant-rotational-speed control and two other dual LVAD control systems: dual constant inlet pressure and dual Frank-Starling control. The results showed that the master/slave physiological control system produced fewer suction events than constant-speed control (6 vs. 62 over a 7-min period). Left/right master/slave control had lower risk of pulmonary congestion than the other control systems, as indicated by lower maximum EDPs (15.1 vs. 25.2-28.4mmHg). During exercise, master/slave control increased total flow from 5.2 to 10.1L/min, primarily due to an increase of left and right pump speed. Use of the left pump as the master resulted in fewer suction events and lower EDPs than when the right pump was master. Based on these results, master/slave control using the left pump as the master automatically adjusts pump speed to avoid suction and increases pump flow during exercise without causing pulmonary venous congestion.
Keyword Biventricular assist device
Heart failure
Rotary pump
Physiological control
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Information Technology and Electrical Engineering Publications
School of Medicine Publications
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