Sensations and regional brain responses evoked by tussive stimulation of the airways

Farrell, M. J. and Mazzone, S. B. (2014) Sensations and regional brain responses evoked by tussive stimulation of the airways. Respiratory Physiology and Neurobiology, 204 58-63. doi:10.1016/j.resp.2014.06.009

Author Farrell, M. J.
Mazzone, S. B.
Title Sensations and regional brain responses evoked by tussive stimulation of the airways
Journal name Respiratory Physiology and Neurobiology   Check publisher's open access policy
ISSN 1569-9048
Publication date 2014-06-19
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.resp.2014.06.009
Open Access Status
Volume 204
Start page 58
End page 63
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract Stimuli that evoke cough in humans also elicit a sensation described as the urge-to-cough. This sensation is perceived at levels of stimulation below the threshold for coughing and increases in intensity in response to higher levels of stimulation. Cough in humans can be consciously modified in intensity or suppressed altogether, and the urge-to-cough is likely to contribute to discretionary responses to tussive stimulation. Converging evidence from animal and human experiments have identified a widely distributed network of brain regions that are implicated in the representation of urge-to-cough and the control of coughing. This network incorporates regions that show responses associated with urge-to-cough ratings, such as limbic and somatosensory cortices, as well as paralimbic and premotor regions implicated in response inhibition that activate in association with efforts to suppress cough. The urge-to-cough can be influenced by psychological factors and preliminary findings suggest that these effects could be mediated by top-down influences. There is considerable impetus to understand circuits involved in the modulation of urge-to-cough because it may be possible to antagonise the troubling sensation while preserving the critical cough reflex.
Keyword Urge-to-cough
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published ahead of print 19 June 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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