Risk factors for idiopathic dystonia in Queensland, Australia

Newman, Jeremy R. B., Boyle, Richard S., O'Sullivan, John D., Silburn, Peter A. and Mellick, George D. (2014) Risk factors for idiopathic dystonia in Queensland, Australia. Journal of Clinical Neuroscience, 21 12: 2145-2149. doi:10.1016/j.jocn.2014.03.032


Author Newman, Jeremy R. B.
Boyle, Richard S.
O'Sullivan, John D.
Silburn, Peter A.
Mellick, George D.
Title Risk factors for idiopathic dystonia in Queensland, Australia
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.jocn.2014.03.032
Open Access Status
Volume 21
Issue 12
Start page 2145
End page 2149
Total pages 5
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Collection year 2015
Language eng
Abstract It is currently hypothesised that a combination of genetic and environmental factors underlies the development of idiopathic isolated dystonia (IID). In this study, we examined several possible environmental or other non-genetic factors that may influence the risk for IID in Queensland, Australia. We surveyed several environmental exposures, lifestyle factors, medical and family histories to investigate potential risk factors for IID. Associations between putative risk factors and IID were assessed using a total of 184 dystonia patients and 1048 neurologically-normal control subjects sampled from Queensland between 2005 and 2012. Our analyses revealed that anxiety disorders, depression, tremor, cigarette smoking and head injuries with a loss of consciousness were associated with increased risk for IID (p < 0.05), all of which remained statistically significant following an adjustment for multiple hypothesis testing except for depression. We also observed that the risk for dystonia increased with higher cigarette smoking pack-year quartiles in our analyses. Our results suggest possible environmental factors that influence the development of IID and complement the findings of similar dystonia risk factor studies. Further investigation defining the environmental and other non-genetic risk factors for IID may provide insight into the development of the disorder in genetically-susceptible individuals.
Keyword Cigarette smoking
Dystonia
Head trauma
Questionnaires
Risk factors
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
 
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