Eph receptors as therapeutic targets in glioblastoma

Day, B. W., Stringer, B. W. and Boyd, A. W. (2014) Eph receptors as therapeutic targets in glioblastoma. British Journal of Cancer, 111 7: 1255-1261. doi:10.1038/bjc.2014.73


Author Day, B. W.
Stringer, B. W.
Boyd, A. W.
Title Eph receptors as therapeutic targets in glioblastoma
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 2014-09-23
Year available 2014
Sub-type Article (original research)
DOI 10.1038/bjc.2014.73
Open Access Status DOI
Volume 111
Issue 7
Start page 1255
End page 1261
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract The dismal outlook for patients with the most aggressive and common form of adult brain cancer, glioblastoma (GBM), motivates a search for new therapeutic strategies and targets for this aggressive disease. Here we review the findings to date on the role of Eph family receptor tyrosine kinases and their ephrin ligands in brain cancer. Expression of the Eph family of cell surface proteins is generally downregulated to very low levels in normal adult tissues making them particularly attractive for directed therapeutic targeting. Recent Eph targeting studies in pre-clinical models of GBM have been very encouraging and may provide an avenue to treat these highly refractory aggressive tumours.
Keyword Eph receptors
Brain cancer
Glioma
Glioblastoma (GBM)
Therapeutic targeting
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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