Connecting the dots between tau dysfunction and neurodegeneration

Frost, Bess, Gotz, Jurgen and Feany, Mel B. (2015) Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology, 25 1: 46-53. doi:10.1016/j.tcb.2014.07.005


Author Frost, Bess
Gotz, Jurgen
Feany, Mel B.
Title Connecting the dots between tau dysfunction and neurodegeneration
Journal name Trends in Cell Biology   Check publisher's open access policy
ISSN 0962-8924
1879-3088
Publication date 2015-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tcb.2014.07.005
Open Access Status
Volume 25
Issue 1
Start page 46
End page 53
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Abstract Tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. Identifying the causes of abnormal tau phosphorylation and subsequent aggregation has been the focus of much research, and is currently a major target for the development of therapeutic interventions for tauopathies, including Alzheimer's disease (AD). Much has recently been learned about the sequence of events that lead from tau dysfunction to neuronal death. This review focuses on the cascade of events that are catalyzed by pathological tau, and highlights current and potential therapeutic strategies to target this pathway.
Keyword Tauopathy
Alzheimer
Actin
Chromatin
Cell cycle
Therapeutics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 26 August 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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