Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis

Law, Soi-Chen, Benham, Helen, Reid, Hugh H., Rossjohn, Jamie and Thomas, Ranjeny (2014) Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis. Rheumatic Disease Clinics of North America, 40 4: 735-752. doi:10.1016/j.rdc.2014.07.015

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Author Law, Soi-Chen
Benham, Helen
Reid, Hugh H.
Rossjohn, Jamie
Thomas, Ranjeny
Title Identification of Self-antigen-specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis
Journal name Rheumatic Disease Clinics of North America   Check publisher's open access policy
ISSN 0889-857X
1558-3163
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.rdc.2014.07.015
Open Access Status
Volume 40
Issue 4
Start page 735
End page 752
Total pages 18
Place of publication Maryland Heights, MO United States
Publisher W.B. Saunders
Collection year 2015
Language eng
Abstract Despite treatment advances, rheumatoid arthritis (RA) is still associated with significant disability, decreased work capacity, and reduced life expectancy. Effective immunotherapies to restore immune tolerance promise greater specificity, lower toxicity, and a longer-term solution to controlling and preventing RA. Design of effective therapies requires a fundamental understanding of the critical immunopathogenetic pathways in RA. This article reviews advances in the understanding of self-antigen-specific T cells in autoimmune diseases including RA and type 1 diabetes, which bring exciting insights to the mechanisms underpinning loss of tolerance and how tolerance could be restored for disease prevention in the preclinical or recent-onset period.
Keyword HLA susceptibility
Immune tolerance
pMHC tetramers
Regulatory T cells
Rheumatoid arthritis
Type 1 diabetes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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