Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras

Salim, Angela A., Cho, Kwang-Jin, Tan, Lingxiao, Quezada, Michelle, Lacey, Ernest, Hancock, John F. and Capon, Robert J. (2014) Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras. Organic Letters, 16 19: 5036-5039. doi:10.1021/ol502376e

Author Salim, Angela A.
Cho, Kwang-Jin
Tan, Lingxiao
Quezada, Michelle
Lacey, Ernest
Hancock, John F.
Capon, Robert J.
Title Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras
Formatted title
Rare Streptomyces N-formyl amino-salicylamides inhibit oncogenic K-Ras
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7052
Publication date 2014-10-03
Sub-type Article (original research)
DOI 10.1021/ol502376e
Open Access Status
Volume 16
Issue 19
Start page 5036
End page 5039
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2015
Language eng
Abstract During a search for inhibitors of oncogenic K-Ras, we detected two known and two new examples of the rare neoantimycin structure class from a liquid cultivation of Streptomyces orinoci, and reassigned/assigned structures to all based on detailed spectroscopic analysis and microscale C3 Marfey’s and C3 Mosher chemical degradation/derivatization/analysis. SAR investigations inclusive of the biosynthetically related antimycins and respirantin, and synthetic benzoxazolone, documented a unique N-formyl amino-salicylamide pharmacophore as a potent inhibitor of oncogenic K-Ras.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
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