Effect of solvent composition and temperature on the solubility of ibuprofen in aqueous ethanol

Rashid, Abdur, White, Edward T., Howes, Tony, Litster, James D. and Marziano, Ivan (2014) Effect of solvent composition and temperature on the solubility of ibuprofen in aqueous ethanol. Journal of Chemical and Engineering Data, 59 9: 2699-2703. doi:10.1021/je400819z


Author Rashid, Abdur
White, Edward T.
Howes, Tony
Litster, James D.
Marziano, Ivan
Title Effect of solvent composition and temperature on the solubility of ibuprofen in aqueous ethanol
Journal name Journal of Chemical and Engineering Data   Check publisher's open access policy
ISSN 0021-9568
1520-5134
Publication date 2014-09
Sub-type Article (original research)
DOI 10.1021/je400819z
Open Access Status
Volume 59
Issue 9
Start page 2699
End page 2703
Total pages 5
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2015
Language eng
Abstract The solubilities of ibuprofen [(R,S)-2-(4-(2-methylpropyl)phenyl)propanoic acid] in absolute ethanol and in water–ethanol mixtures were measured at temperatures from 10 °C to 40 °C, the expected range relevant to its industrial crystallization. The solubility studies were carried out by dissolution of ibuprofen crystals in stirred Schott bottles kept in a constant temperature bath. The ibuprofen concentration in the clear supernatant at equilibrium was determined by vacuum drying. An allowance was made for the small amount of sublimation from dried ibuprofen. In absolute ethanol, the experimental results showed that the solubility increased as a square law with temperature, from 0.59 g of ibuprofen/g ethanol at 10.0 °C to 2.15 g/g at 40.0 °C. The results are considered to be accurate to within ±1% (as 95% confidence). In water–ethanol mixtures, the solubility of ibuprofen (expressed as w/w ibuprofen/solvent) generally decreased with increasing water addition. At 40 °C and possibly at 25 °C, the solubility initially increased slightly to a maximum level as a small amount of water was added before then decreasing. At 40 °C, phase separation into two immiscible liquid layers was observed for solvent concentrations from 34 to 64% ethanol on an ibuprofen-free basis.
Keyword 1,4-Dioxane-Water Mixtures
Phase-Separation
Drug Solubility
Pure Solvents
Water
Acid
Model
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
Official 2015 Collection
 
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