Maternal lipids in pre-eclampsia: innocent bystander or culprit?

Barrett, Helen L., Dekker Nitert, Marloes, McIntyre, H. David and Callaway, Leonie K. (2014) Maternal lipids in pre-eclampsia: innocent bystander or culprit?. Hypertension in Pregnancy, 33 4: 508-523. doi:10.3109/10641955.2014.946614


Author Barrett, Helen L.
Dekker Nitert, Marloes
McIntyre, H. David
Callaway, Leonie K.
Title Maternal lipids in pre-eclampsia: innocent bystander or culprit?
Journal name Hypertension in Pregnancy   Check publisher's open access policy
ISSN 1064-1955
1525-6065
Publication date 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3109/10641955.2014.946614
Open Access Status
Volume 33
Issue 4
Start page 508
End page 523
Total pages 16
Place of publication New York, NY, United States
Publisher Informa Healthcare
Collection year 2015
Language eng
Abstract Pre-eclampsia continues to be a challenge – to understand the underlying pathogenesis and to prevent or treat in the clinical setting. One area of potential therapies opening up is treatment of maternal lipids and clinical trials are underway using statins in early pre-eclampsia. At present, most potential therapies to treat lipids cannot be recommended for general use in pregnancy and if we were to target maternal lipids to reduce rates of pre-eclampsia, very large numbers of women may need to be treated. Prior to reaching that point, we first need to understand whether maternal lipids are pathogenic in the processes underlying pre-eclampsia. The aim of this review is to examine the role of lipids in the pathogenesis and outcomes of pre-eclampsia, how abnormal lipid genes may be implicated and consider whether treatment of hyperlipidemia has a more general place in the prevention or treatment of pre-eclampsia
Keyword Lipids
Pre-eclampsia
Pregnancy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Medicine Publications
 
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Created: Thu, 16 Oct 2014, 15:02:26 EST by Marloes Dekker on behalf of Royal Brisbane Clinical School