New insights on contraction efficiency in patients with Duchenne muscular dystrophy

Lacourpaille, Lilian, Hug, Francois, Guevel, Arnaud, Pereon, Yann, Magot, Armelle, Hogrel, Jean-Yves and Nordez, Antoine (2014) New insights on contraction efficiency in patients with Duchenne muscular dystrophy. Journal of Applied Physiology, 117 6: 658-662. doi:10.1152/japplphysiol.00544.2014

Author Lacourpaille, Lilian
Hug, Francois
Guevel, Arnaud
Pereon, Yann
Magot, Armelle
Hogrel, Jean-Yves
Nordez, Antoine
Title New insights on contraction efficiency in patients with Duchenne muscular dystrophy
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 2014-09-15
Year available 2014
Sub-type Article (original research)
DOI 10.1152/japplphysiol.00544.2014
Open Access Status
Volume 117
Issue 6
Start page 658
End page 662
Total pages 5
Place of publication Bethesda MD, United States
Publisher American Physiological Society
Collection year 2015
Language eng
Abstract The decrease in muscle strength in patients with Duchenne muscular dystrophy (DMD) is mainly explained by a decrease in the number of active contractile elements. Nevertheless, it is possible that other electrochemical and force transmission processes may contribute. The present study aimed to quantify the effect of DMD on the relative contribution of electrochemical and force transmission components of the electromechanical delay (i.e., time lag between the onset of muscle activation and force production) in humans using very high frame rate ultrasound. Fourteen patients with DMD and thirteen control subjects underwent two electrically evoked contractions of the biceps brachii with the ultrasound probe over the muscle belly. The electromechanical delay was significantly longer in DMD patients compared with controls (18.5 ± 3.9 vs. 12.5 ± 1.4 ms, P < 0.0001). More precisely, DMD patients exhibited a longer delay between the onset of muscle fascicles motion and force production (13.6 ± 3.1 vs. 7.9 ± 2.0 ms, P < 0.0001). This delay was correlated to the chronological age of the DMD patients (r = 0.66; P = 0.01), but not of the controls (r = −0.45; P = 0.10). No significant difference was found for the delay between the onset of muscle stimulation and the onset of muscle fascicle motion. These results highlight the role of the alteration of muscle force transmission (delay between the onset of fascicle motion and force production) in the impairments of the contraction efficiency in patients with DMD.
Keyword Myopathy
Electromechanical delay
Electromechanical delay components
Skeletal-Muscle Fibers
Mdx Mice
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Health and Rehabilitation Sciences Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 12 Oct 2014, 00:30:44 EST by System User on behalf of School of Health & Rehabilitation Sciences