Research report: Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle

Soos, MA, Jensen, J, Brown, RA, O'Rahilly, S, Shepherd, PR and Whitehead, JP (2001) Research report: Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle. Archives of Biochemistry and Biophysics, 396 2: 244-248. doi:10.1006/abbi.2001.2587


Author Soos, MA
Jensen, J
Brown, RA
O'Rahilly, S
Shepherd, PR
Whitehead, JP
Title Research report: Class II phosphoinositide 3-kinase is activated by insulin but not by contraction in skeletal muscle
Journal name Archives of Biochemistry and Biophysics   Check publisher's open access policy
ISSN 0003-9861
Publication date 2001-12-15
Sub-type Article (original research)
DOI 10.1006/abbi.2001.2587
Volume 396
Issue 2
Start page 244
End page 248
Total pages 5
Language eng
Subject 1303 Specialist Studies in Education
1304 Biophysics
1312 Molecular Biology
Abstract While the role of the class IA phosphoinositide 3-kinase (PI 3-kinase) in insulin signaling is well established, little is known about the role of the class II PI 3-kinases. We show that insulin stimulation of intact rat soleus and epitrochlearis muscles causes a 3- to 4-fold increase in the activity of the wortmannin-resistant alpha isoform of the class II PI 3-kinase (PI3K-C2α). This activation is rapid and parallels the insulin-induced activation of the class IA PI 3-kinase associated with IRS-1 in these muscles. However, while contraction activated p38 Map kinase, it did not stimulate the activity of the class II PI 3-kinase. Therefore, activation of class II PI 3-kinase is unlikely to provide a mechanism that explains the fact that exercise-induced activation of glucose uptake is not blocked by wortmannin. However, the results suggest that activation of class II PI 3-kinase is likely to play a role in insulin signaling pathways in skeletal muscle.
Keyword Exercise
Insulin
Muscle
Phosphoinositide 3-kinase
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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