Structure, signalling and physiologic role of adiponectin-dietary and exercise-related variations

Hickman, I. J. and Whitehead, J. P. (2012) Structure, signalling and physiologic role of adiponectin-dietary and exercise-related variations. Current Medicinal Chemistry, 19 32: 5427-5443. doi:10.2174/092986712803833155


Author Hickman, I. J.
Whitehead, J. P.
Title Structure, signalling and physiologic role of adiponectin-dietary and exercise-related variations
Journal name Current Medicinal Chemistry   Check publisher's open access policy
ISSN 0929-8673
Current Medicinal Chemistry 1875-533X
Publication date 2012-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/092986712803833155
Open Access Status
Volume 19
Issue 32
Start page 5427
End page 5443
Total pages 17
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Formatted abstract
Since its discovery in 1995 adiponectin has garnered considerable interest from the academic, clinical and biotech communities due to its proposed salutary anti-inflammatory, anti-diabetic, anti-atherogenic and cardioprotective properties. As a result our appreciation of adiponectin's structure and the importance of post-translational modifications (PTMs) in adiponectin production are now relatively advanced. So too, following the identification of a variety of adiponectin receptors, binding proteins and downstream signalling networks, is our understanding of adiponectin's intracellular signalling pathways that are implicated in mediating adiponectin's pleiotropic effects. Adiponectin's ability to moderate inflammation, which is recognised as a key protagonist in many modern diseases, may be the key to many of its beneficial effects. Recent insights indicate that adiponectin modulates cellular inflammation by affecting sphingolipid metabolism, with the adiponectin receptors displaying intrinsic ceramidase activity. In the current review we will summarise the molecular details of adiponectin, discuss key players and recent insights into adiponectin signalling and consider the physiologic role(s) of adiponectin. We will also review studies into the effects of diet or exercise on circulating adiponectin levels focusing largely on reports from human trials.
Keyword Adipokines
Cardiovascular disease
Diabetes
Inflammation
Receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Mater Research Institute-UQ (MRI-UQ)
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 07 Oct 2014, 12:45:14 EST by System User on behalf of Mater Research Institute-UQ