Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults

Larsen, R. N., Kingwell, B. A., Sethi, P., Cerin, E., Owen, N. and Dunstan, D. W. (2014) Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults. Nutrition, Metabolism and Cardiovascular Diseases, 24 9: 976-982. doi:10.1016/j.numecd.2014.04.011

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ341207_OA.pdf Full text (open access) application/pdf 784.90KB 1

Author Larsen, R. N.
Kingwell, B. A.
Sethi, P.
Cerin, E.
Owen, N.
Dunstan, D. W.
Title Breaking up prolonged sitting reduces resting blood pressure in overweight/obese adults
Journal name Nutrition, Metabolism and Cardiovascular Diseases   Check publisher's open access policy
ISSN 0939-4753
Publication date 2014-09
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.numecd.2014.04.011
Open Access Status
Volume 24
Issue 9
Start page 976
End page 982
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Aim: To compare the effect of 7 h of prolonged sitting on resting blood pressure with a similar duration of sitting combined with intermittent brief bouts of light-intensity or moderate-intensity physical activity.

Methods and results: Overweight/obese adults (n = 19; aged 45-65 years) were recruited for a randomized three-treatment crossover trial with a one-week washout between treatments: 1) uninterrupted sitting; 2) sitting with 2 min bouts of light-intensity walking at 3.2 km/h every 20 min; and, 3) sitting with 2 min bouts of moderate-intensity walking at between 5.8 and 6.4 km/h every 20 min. After an initial 2 h period seated, participants consumed a test meal (75 g carbohydrate, 50 g fat) and completed each condition over the next 5 h. Resting blood pressure was assessed oscillometrically every hour as a single measurement, 5 min prior to each activity bout. GEE models were adjusted for sex, age, BMI, fasting blood pressure and treatment order. After adjustment for potential confounding variables, breaking up prolonged sitting with light and moderate-intensity activity breaks was associated with lower systolic blood pressure [light: 120 ± 1 mmHg (estimated marginal mean ± SEM), P = 0.002; moderate: 121 ± 1 mmHg, P = 0.02], compared to uninterrupted sitting (123 ± 1 mmHg). Diastolic blood pressure was also significantly lower during both of the activity conditions (light: 76 ± 1 mmHg, P = 0.006; moderate: 77 ± 1 mmHg, P = 0.03) compared to uninterrupted sitting (79 ± 1 mmHg). No significant between-condition differences were observed in mean arterial pressure or heart rate.

Conclusion: Regularly breaking up prolonged sitting may reduce systolic and diastolic blood pressure.

Trial registration number: ACTRN12609000656235 (

Trial registration date: August 4th 2009.
Keyword Sedentary behavior
Physical activity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 05 Oct 2014, 01:00:28 EST by System User on behalf of School of Public Health