Vaccine strategies to treat lymphoproliferative disorders

Radford, Kristen J., Vari, Frank and Hart, Derek N. J. (2005) Vaccine strategies to treat lymphoproliferative disorders. Pathology, 37 6: 534-550. doi:10.1080/00313020500376462


Author Radford, Kristen J.
Vari, Frank
Hart, Derek N. J.
Title Vaccine strategies to treat lymphoproliferative disorders
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 2005-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/00313020500376462
Open Access Status Not yet assessed
Volume 37
Issue 6
Start page 534
End page 550
Total pages 17
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Lymphoproliferative disorders, including follicular lymphoma (FL), multiple myeloma (MM) and chronic lymphatic leukaemia (CLL), are slowly progressive malignancies which remain incurable despite advances in therapy. Harnessing the immune system to recognise and destroy tumours is a promising new approach to treating these diseases. Dendritic cells (DC) are unique antigen-presenting cells that play a central role in the initiation and direction of immune responses. DC loaded ex vivo with tumour-associated antigens and administered as a vaccine have already shown promise in early clinical trials for a number of lymphoproliferative disorders, but the need for improvement is widely agreed. Recent advances in the understanding of basic DC biology and lessons from early clinical trials have provided exciting new insights into the generation of anti-tumour immune responses and the design of vaccine strategies. In this review we provide an overview of our current understanding of DC biology and their function in patients with lymphoproliferative disorders. We discuss the current status of clinical trials and new approaches to exploit the antigen presenting capacity of DC to design vaccines of the future.
Keyword Chronic lymphocytic leukaemia
Clinical trials
Dendritic cells
Follicular lymphoma
Immunotherapy
Multiple myeloma
Vaccines
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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