Monitoring children’s language development following intrathecal chemotherapy for acute lymphoblastic leukaemia

Lewis, Fiona M. and Chai, Jaymie (2015) Monitoring children’s language development following intrathecal chemotherapy for acute lymphoblastic leukaemia. Speech, Language and Hearing, 18 1: 2-15. doi:10.1179/2050572814Y.0000000048


Author Lewis, Fiona M.
Chai, Jaymie
Title Monitoring children’s language development following intrathecal chemotherapy for acute lymphoblastic leukaemia
Journal name Speech, Language and Hearing   Check publisher's open access policy
ISSN 2050-571X
2050-5728
Publication date 2015-01-01
Sub-type Article (original research)
DOI 10.1179/2050572814Y.0000000048
Volume 18
Issue 1
Start page 2
End page 15
Total pages 14
Place of publication Leeds, W Yorks, United Kingdom
Publisher Maney Publishing
Collection year 2016
Language eng
Formatted abstract
The majority of children diagnosed with acute lymphoblastic leukaemia (ALL) become long-term survivors. Hence, much emphasis is placed on optimising survivorship. Previous studies have used point-in-time language assessments to describe language outcomes subsequent to intrathecal chemotherapy (ITC), but this method of monitoring may be misleading in the absence of pre-morbid performance data. In the current study, we demonstrate the use of developmental trajectories to individually track the language development of eight children (M age at diagnosis = 4.8 years; M age at initial language assessment = 7.6 years) with a history of ALL treated with ITC. Basic and high-level language skills were assessed at a minimum of two assessment points over 2 years. Local comparative data were obtained from age- and sex-matched control participants (M age at initial assessment = 7.10 years). The skill development relevant to each test was tracked over time using the raw scores attained by each child treated for ALL, the average raw scores of his/her control group, and the test's raw scores at the 50th percentile (test average). Results revealed variability in language outcomes. With long-term negative impacts of chemotherapy calling for extended monitoring of children post-treatment, the use of developmental trajectories to track language development over time serves as an efficient, sensitive tool for providing follow-up services for children treated with ITC. Individualised language intervention can promptly commence when a child's performance deviates from expected trajectories.
Keyword Acute lymphoblastic leukaemia
Intrathecal chemotherapy
Language trajectory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2016 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Mon, 29 Sep 2014, 23:24:27 EST by Dr Fiona Lewis on behalf of School of Health & Rehabilitation Sciences