Immunohistochemical profile of ductal adenocarcinoma of the prostate

Seipel, Amanda H., Samaratunga, Hemamali, Delahunt, Brett, Wiklund, Fredrik, Wiklund, Peter, Lindberg, Johan, Grönberg, Henrik and Egevad, Lars (2014) Immunohistochemical profile of ductal adenocarcinoma of the prostate. Virchows Archiv, 465 5: 559-565. doi:10.1007/s00428-014-1636-0

Author Seipel, Amanda H.
Samaratunga, Hemamali
Delahunt, Brett
Wiklund, Fredrik
Wiklund, Peter
Lindberg, Johan
Grönberg, Henrik
Egevad, Lars
Title Immunohistochemical profile of ductal adenocarcinoma of the prostate
Journal name Virchows Archiv   Check publisher's open access policy
ISSN 0945-6317
Publication date 2014-07-25
Sub-type Article (original research)
DOI 10.1007/s00428-014-1636-0
Open Access Status
Volume 465
Issue 5
Start page 559
End page 565
Total pages 7
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Formatted abstract
Ductal adenocarcinoma of the prostate (DAC) is considered to be an aggressive subtype of prostate cancer with greater risk of progression than acinar adenocarcinoma (AC). It has been debated whether DAC is a distinct subtype or a morphological variant of AC. Our aim was to examine the protein expression of DAC and to compare the results with AC. A tissue microarray was constructed from 60 DAC and 46 AC matched by Gleason score. The slides were stained for 28 immunomarkers (estrogen, progesterone and androgen receptor, prolactin, PSA, prostein, PSMA, PSAP, CDX2, lysozyme, villin, monoclonal CEA, CK7, CK20, HMWCK, p63, p504s, c-myc, EGFR, Ki-67, p16, p21, p27, p53, PTEN, ERG, PAX-2, and PAX-8). HMWCK was positive in 8.5 % of DAC, but negative in all cases of AC (p = 0.045). p16 was positive in 53.3 % of DAC and in 26.1 % of AC (p = 0.005). p53 was positive in 42.4 % of DAC and 26.7 % of AC (p = 0.031). A distinct patchy positivity of CK20 was seen in 23.7 % of DAC, and this pattern was also seen in 9.1 % of AC (p = 0.047). Villin was positive in 3.4 % of DAC while expression was negative in AC. Ki-67 labeling index was significantly higher in DAC than in AC (mean 9.2 % [95 % CI 6.4-12.0] and 2.6 % [1.9-3.4], p < 0.001). While there is some overlap in the immunohistochemical expression of DAC and AC, the differences between these two morphotypes of prostatic carcinoma are consistent with DAC having a more aggressive phenotype than AC.
Keyword Ductal cancer
Prostate cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 29 Sep 2014, 13:03:05 EST by Anthony Yeates on behalf of Discipline of Molecular and Cellular Pathology