Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide

Moradi, S. V., Varamini, P. and Toth, I. (2014). Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide. In: Dr. Bert L. Schram Young Investigators' Mini Symposium. Abstracts. Dr. Bert L. Schram Young Investigators' Mini-Symposium. 33EPS 2014: 33rd European Peptide Symposium, Sofia, Bulgaria, (S38-S38). 31 August-5 September, 2014. doi:10.1002/psc.2686


Author Moradi, S. V.
Varamini, P.
Toth, I.
Title of paper Glycosylation of luteninzing hormone releasing hormoe: towards the development of orally active peptide
Conference name Dr. Bert L. Schram Young Investigators' Mini-Symposium. 33EPS 2014: 33rd European Peptide Symposium
Conference location Sofia, Bulgaria
Conference dates 31 August-5 September, 2014
Proceedings title Dr. Bert L. Schram Young Investigators' Mini Symposium. Abstracts   Check publisher's open access policy
Journal name Journal of Peptide Science   Check publisher's open access policy
Place of Publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Publication Year 2014
Sub-type Published abstract
DOI 10.1002/psc.2686
ISSN 1075-2617
1099-1387
Volume 20
Issue Supp. 1
Start page S38
End page S38
Total pages 1
Language eng
Formatted Abstract/Summary
Luteinizing hormone releasing hormone (LHRH) is a decapeptide and plays a crucial role in the regulation of reproductive system in both male and female. Due to the extensive application of this hormone for the treatment hormone dependent diseases such as breast and prostate cancers, developing an orally active peptide is highly demanded. However, the poor bioavailability and rapid enzymatic degradation of the peptide impede the progress in developing a potent oral analogue. The main aim of this research was to change the pharmacokinetic profile of LHRH peptide and enhance its oral bioavailability using glycosylation strategy...
Keyword LHRH
Glycosylation
Caco-2 cell monolayer
Active transporters
GLUT and SGLT
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Meeting Abstract YO9.

 
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Created: Fri, 26 Sep 2014, 20:28:45 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences