Pagetoid squamous cell carcinoma in situ of the vulva: Comparison with extramammary Paget disease and nonpagetoid squamous cell neoplasia

Armes, Jane E., Lourie, Rohan, Bowlay, Greg and Tabrizi, Sepehr (2008) Pagetoid squamous cell carcinoma in situ of the vulva: Comparison with extramammary Paget disease and nonpagetoid squamous cell neoplasia. International Journal of Gynecological Pathology, 27 1: 118-124. doi:10.1097/pgp.0b013e318142acf0


Author Armes, Jane E.
Lourie, Rohan
Bowlay, Greg
Tabrizi, Sepehr
Title Pagetoid squamous cell carcinoma in situ of the vulva: Comparison with extramammary Paget disease and nonpagetoid squamous cell neoplasia
Formatted title
Pagetoid squamous cell carcinoma in situ of the vulva: Comparison with extramammary Paget disease and nonpagetoid squamous cell neoplasia
Journal name International Journal of Gynecological Pathology   Check publisher's open access policy
ISSN 0277-1691
1538-7151
Publication date 2008-01-01
Sub-type Article (original research)
DOI 10.1097/pgp.0b013e318142acf0
Volume 27
Issue 1
Start page 118
End page 124
Total pages 7
Place of publication Philadelphia United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2734 Pathology and Forensic Medicine
2729 Obstetrics and Gynaecology
Formatted abstract
Pagetoid squamous cell carcinoma in situ (PSSCIS) is a variant of squamous cell intraepithelial neoplasia. Although PSSCIS is well-documented in the cutaneous skin and esophagus, cases of vulvar PSSCIS are rare. In the vulva, the main differential diagnosis is extramammary Paget disease (EMPD). We report 2 cases of vulvar PSSCIS along with the immunohistochemical and human papillomavirus (HPV) status of this disease compared with primary cutaneous EMPD of the vulva. Although PSSCIS and EMPD share CK7 and CK19 expression, PSSCIS is consistently mucin and carcinoembryonic antigen negative. In contrast to EMPD, both cases of PSSCIS strongly expressed p16 (INK4A) protein, consistent with RB1 protein dysregulation. However, integration of high-risk HPV was found in only 1 of the 2 PSSCIS cases. Given the morphological and immunohistochemical findings, we suggest that PSSCIS arises from a bidirectional stem cell capable of both squamous and glandular differentiation. Additionally, as with nonpagetoid squamous cell neoplasias of the vulvar, integration of high-risk HPV may occur in some, but not all, cases of PSSCIS.
Keyword Paget disease
Pagetoid Bowen disease
Pagetoid cells
Pagetoid squamous cell carcinoma in situ
Vulva
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 22 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 27 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 25 Sep 2014, 18:53:56 EST by System User on behalf of Mater Research Institute-UQ