Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein

Armes, Jane E., Lourie, Rohan, de Silva, Melanie, Stamaratis, Georgia, Boyd, Alison, Kumar, Beena, Price, Gareth, Hyde, Simon, Allen, David, Grant, Peter and Venter, Deon J. (2005) Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein. International Journal of Gynecological Pathology, 24 4: 363-368. doi:10.1097/01.pgp.0000172083.94934.1e


Author Armes, Jane E.
Lourie, Rohan
de Silva, Melanie
Stamaratis, Georgia
Boyd, Alison
Kumar, Beena
Price, Gareth
Hyde, Simon
Allen, David
Grant, Peter
Venter, Deon J.
Title Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein
Journal name International Journal of Gynecological Pathology   Check publisher's open access policy
ISSN 0277-1691
1538-7151
Publication date 2005-10
Sub-type Article (original research)
DOI 10.1097/01.pgp.0000172083.94934.1e
Open Access Status Not yet assessed
Volume 24
Issue 4
Start page 363
End page 368
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Dysfunction of proteins involved in the G1 to S transition of the cell cycle, such as p16(INK4A) and RB1, is common in many cancer types. A screen of p16 protein expression was performed in benign, borderline, and invasive ovarian tumors, together with endometrial cancers, aligned on a tissue microarray. We observed frequent p16 overexpression in serous papillary carcinomas of ovarian and endometrial origin. An extended cohort of ovarian serous papillary carcinomas was examined to further evaluate the frequency of p16 overexpression. Strong, uniform staining in the majority of cancer cells occurred commonly in invasive serous papillary ovarian cancers, particularly in grade 3 carcinomas. RB1 protein expression abnormalities were rare. Our data indicate that abnormalities in the retinoblastoma pathway, as determined by p16 overexpression, are common in serous papillary carcinomas and are probably an early event.
Keyword Ovarian cancer
P16
RB1 pathway
Tissue microarrays
Immunohistochemistry
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
School of Medicine Publications
 
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