Differential diagnosis of serous papillary carcinoma of the gynaecological tract and basal breast carcinoma: An immunohistochemical approach

Armes, Jane E., Bowlay, Greg, Lourie, Rohan, Venter, Deon J. and Price, Gareth (2010) Differential diagnosis of serous papillary carcinoma of the gynaecological tract and basal breast carcinoma: An immunohistochemical approach. Pathology, 42 6: 534-539. doi:10.3109/00313025.2010.508793


Author Armes, Jane E.
Bowlay, Greg
Lourie, Rohan
Venter, Deon J.
Price, Gareth
Title Differential diagnosis of serous papillary carcinoma of the gynaecological tract and basal breast carcinoma: An immunohistochemical approach
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
1465-3931
Publication date 2010-10
Sub-type Article (original research)
DOI 10.3109/00313025.2010.508793
Open Access Status
Volume 42
Issue 6
Start page 534
End page 539
Total pages 6
Place of publication London United Kingdom
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Aims:
There is a high frequency of serous gynaecological and basal breast cancers in patients with germline BRCA1 mutations. These patients often undergo prophylactic salpingo-oophorectomies, where small tumours may be identified in which morphological distinction between primary serous and metastatic basal breast cancer may be problematic. These two cancer types share similar molecular genetics and have immunophenotypic overlap. We aimed to develop an immunohistochemical panel which could differentiate between these two tumour types.

Methods:
Immunohistochemistry was performed on a training set of 20 serous gynaecological and 20 basal breast cancers, from which a small differential panel was developed. This differential panel was tested in an additional validation set of serous and basal cancers.

Results:
WT1, ER and CK5/6 expression successfully differentiated serous gynaecological and basal breast cancers. WT1 and ER expression was significantly more common in serous cancers and CK5/6 expression more common in basal cancers.

Conclusion:
There is considerable genetic, morphological and immunophenotypic overlap between serous gynaecological and basal breast cancers. A limited panel of WT1, ER and CK5/6 was found to optimally differentiate these tumour types. Differences in the expression of these proteins appear to reflect the expression pattern of their cell of origin, rather than identify aberrant oncogenic pathways.
Keyword Basal breast carcinoma
Breast
Gynaecological
Immunohistochemistry
Serous papillary carcinoma of gynaecological tract
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
 
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