Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers

Armes, Jane E., Hammet, Fleur, de Silva, Melanie, Ciciulla, John, Ramus, Susan J., Soo, Wee-Kheng, Mahoney, Alexis, Yarovaya, Natalia, Henderson, Michael A., Gish, Kurt, Hutchins, Anne-Marie, Price, Gareth R. and Venter, Deon J. (2004) Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers. Oncogene, 23 33: 5697-5702. doi:10.1038/sj.onc.1207740

Author Armes, Jane E.
Hammet, Fleur
de Silva, Melanie
Ciciulla, John
Ramus, Susan J.
Soo, Wee-Kheng
Mahoney, Alexis
Yarovaya, Natalia
Henderson, Michael A.
Gish, Kurt
Hutchins, Anne-Marie
Price, Gareth R.
Venter, Deon J.
Title Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
Publication date 2004-07-22
Sub-type Article (original research)
DOI 10.1038/sj.onc.1207740
Open Access Status Not yet assessed
Volume 23
Issue 33
Start page 5697
End page 5702
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Loss of genetic material from chromosome arm 8p occurs commonly in breast carcinomas, suggesting that this region is the site of one or more tumor-suppressor genes (TSGs). Comparative genomic hybridization analysis showed that 8p loss is more common in breast cancers from pre-menopausal compared with post-menopausal patients, as well as in high-grade breast cancers, regardless of the menopausal status. Subsequent high-resolution gene expression profiling of genes mapped to chromosome arm 8p, on an extended cohort of clinical tumor samples, indicated a similar dichotomy of breast cancer clinicopathologic types. Some of these genes showed differential downregulation in early-onset and later-onset, high-grade cancers compared with lower-grade, later-onset cancers. Three such genes were analysed further by in situ technologies, performed on tissue microarrays representing breast tumor and normal tissue samples. PCM1, which encodes a centrosomal protein, and DUSP4/MKP-2, which encodes a MAP kinase phosphatase, both showed frequent gene and protein loss in carcinomas. In contrast, there was an excess of cases showing loss of expression in the absence of reduced gene copy number of SFRP1, which encodes a dominant-negative receptor for Wnt-family ligands. These candidate TSGs may constitute some of the molecular drivers of chromosome arm 8p loss in breast carcinogenesis.
Keyword Breast cancer
Chromosome 8
Comparative genomic hybridization
Expression microarrays
Tumor-suppressor genes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
School of Medicine Publications
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