Detailed gene copy number and RNA expression analysis of the 17q12-23 region in primary breast cancers

Willis, S, Hutchins, AM, Hammet, F, Ciciulla, J, Soo, WK, White, D, van der Spek, P, Henderson, MA, Gish, K, Venter, DJ and Armes, JE (2003) Detailed gene copy number and RNA expression analysis of the 17q12-23 region in primary breast cancers. Genes Chromosomes and Cancer, 36 4: 382-392. doi:10.1002/gcc.10138


Author Willis, S
Hutchins, AM
Hammet, F
Ciciulla, J
Soo, WK
White, D
van der Spek, P
Henderson, MA
Gish, K
Venter, DJ
Armes, JE
Title Detailed gene copy number and RNA expression analysis of the 17q12-23 region in primary breast cancers
Journal name Genes Chromosomes and Cancer   Check publisher's open access policy
ISSN 1045-2257
Publication date 2003-04-01
Sub-type Article (original research)
DOI 10.1002/gcc.10138
Volume 36
Issue 4
Start page 382
End page 392
Total pages 11
Language eng
Subject 1306 Cancer Research
1311 Genetics
Abstract Chromosome region 17q12-23 commonly shows an increase in DNA copy number in breast cancers, suggesting that several oncogenes are located at this site. We performed a high-resolution expression array and comparative genomic hybridization analysis of genes mapped to the entire 17q12-23 region, to identify novel candidate oncogenes. We identified 24 genes that showed significant overexpression in breast cancers with gain of 17q12-23, compared to cancers without gain. These genes included previously identified oncogenes, together with several novel candidate oncogenes. FISH analysis using specific gene probes hybridized to tissue arrays confirmed the underlying amplification of overexpressed genes. This high-resolution analysis of the 17q12-23 region indicates that several established and novel candidate oncogenes, including a Wnt-signaling pathway member, are amplified and overexpressed within individual primary breast cancer samples. We were also able to confirm the presence of two apparently separate and reciprocally amplified groups of genes within this region. Investigation of these genes and their functional interactions will facilitate our understanding of breast oncogenesis and optimal management of this disease.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
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