The use of biomaterials in islet transplantation

Borg, Danielle J. and Bonifacio, Ezio (2011) The use of biomaterials in islet transplantation. Current Diabetes Reports, 11 5: 434-444. doi:10.1007/s11892-011-0210-2

Author Borg, Danielle J.
Bonifacio, Ezio
Title The use of biomaterials in islet transplantation
Journal name Current Diabetes Reports   Check publisher's open access policy
ISSN 1534-4827
Publication date 2011-10
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11892-011-0210-2
Open Access Status DOI
Volume 11
Issue 5
Start page 434
End page 444
Total pages 11
Place of publication Philadelphia United States
Publisher Springer Healthcare
Language eng
Subject 2712 Endocrinology, Diabetes and Metabolism
2724 Internal Medicine
Abstract Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however, inflammation, the required immunosuppression, and lack of vasculature decrease early islet viability and function. Therefore, the use of accessory therapy and biomaterials to protect islets and improve islet function has definite therapeutic potential. Here we review the application of niche accessory cells and factors, as well as the use of biomaterials as carriers or capsules, for pancreatic islet transplantation.
Keyword Biomaterial
Islet niche
Islet transplantation
Type 1 diabetes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 24 Sep 2014, 11:10:53 EST by Ms Kate Rowe on behalf of School of Biomedical Sciences