Obesity gene NEGR1 associated with white matter integrity in healthy young adults

Dennis, Emily L., Jahanshad, Neda, Braskie, Meredith N., Warstadt, Nicholus M., Hibar, Derrek P., Kohannim, Omid, Nir, Talia M., McMahon, Katie L., de Zubicaray, Greig I., Montgomery, Grant W., Martin, Nicholas G., Toga, Arthur W., Wright, Margaret J. and Thompson, Paul M. (2014) Obesity gene NEGR1 associated with white matter integrity in healthy young adults. Neuroimage, 102 Part 2: 548-557. doi:10.1016/j.neuroimage.2014.07.041


Author Dennis, Emily L.
Jahanshad, Neda
Braskie, Meredith N.
Warstadt, Nicholus M.
Hibar, Derrek P.
Kohannim, Omid
Nir, Talia M.
McMahon, Katie L.
de Zubicaray, Greig I.
Montgomery, Grant W.
Martin, Nicholas G.
Toga, Arthur W.
Wright, Margaret J.
Thompson, Paul M.
Title Obesity gene NEGR1 associated with white matter integrity in healthy young adults
Formatted title
Obesity gene NEGR1 associated with white matter integrity in healthy young adults
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2014-11-15
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2014.07.041
Open Access Status
Volume 102
Issue Part 2
Start page 548
End page 557
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract Obesity is a crucial public health issue in developed countries, with implications for cardiovascular and brain health as we age. A number of commonly-carried genetic variants are associated with obesity. Here we aim to see whether variants in obesity-associated genes - NEGR1, FTO, MTCH2, MC4R, LRRN6C, MAP2K5, FAIM2, SEC16B, ETV5, BDNF- AS, ATXN2L, ATP2A1, KCTD15, and TNN13K - are associated with white matter microstructural properties, assessed by high angular resolution diffusion imaging (HARDI) in young healthy adults between 20 and 30. years of age from the Queensland Twin Imaging study (QTIM). We began with a multi-locus approach testing how a number of common genetic risk factors for obesity at the single nucleotide polymorphism (SNP) level may jointly influence white matter integrity throughout the brain and found a wide spread genetic effect. Risk allele rs2815752 in NEGR1 was most associated with lower white matter integrity across a substantial portion of the brain. Across the area of significance in the bilateral posterior corona radiata, each additional copy of the risk allele was associated with a 2.2% lower average FA. This is the first study to find an association between an obesity risk gene and differences in white matter integrity. As our subjects were young and healthy, our results suggest that NEGR1 has effects on brain structure independent of its effect on obesity.
Keyword Diffusion tensor imaging
Genetics
HARDI
Multi-locus
Obesity
SNP
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Psychology Publications
Centre for Advanced Imaging Publications
 
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Created: Thu, 18 Sep 2014, 11:22:59 EST by Shona Osborne on behalf of Centre for Advanced Imaging