The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent

D'Ambrosio, R., Aghemo, A., De Francesco, R., Rumi, M. G., Galmozzi, E., De Nicola, S., Cheroni, C., Clark, P. J., Ronchi, G., Lampertico, P. and Colombo, M. (2014) The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent. International Journal of Molecular Sciences, 15 5: 7213-7224. doi:10.3390/ijms15057213

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Author D'Ambrosio, R.
Aghemo, A.
De Francesco, R.
Rumi, M. G.
Galmozzi, E.
De Nicola, S.
Cheroni, C.
Clark, P. J.
Ronchi, G.
Lampertico, P.
Colombo, M.
Title The association of Il28b genotype with the histological features of chronic hepatitis C Is HCV genotype dependent
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1422-0067
1661-6596
Publication date 2014-04-25
Sub-type Article (original research)
DOI 10.3390/ijms15057213
Open Access Status DOI
Volume 15
Issue 5
Start page 7213
End page 7224
Total pages 12
Place of publication Basel, Switzerland
Publisher Molecular Diversity Preservation International
Collection year 2015
Language eng
Subject 1312 Molecular Biology
Abstract The interleukin 28B (IL28B) rs12979860 polymorphism is associated with treatment outcome in hepatitis C virus (HCV) genotype 1 and 4 patients. Its association with the histological features of chronic hepatitis C and disease severity needs further clarifications. To assess the correlation between IL28B genotype, HCV genotype and liver biopsy findings in untreated patients. Materials and Methods: Pre-treatment liver biopsies from 335 HCV Caucasian patients (59% males, age 50 years) enrolled in the MIST study were staged for fibrosis and inflammation according to the METAVIR and the Ishak scoring systems; steatosis was dichotomized as <5% or ≥5%. IL28B was typed by Taqman Single Nucleotide Polymorphism (SNP) genotyping assay. HCV genotype was 1 in 151 (45%), 2 in 99 (30%), 3 in 50 (15%) and 4 in 35 (10%) patients. IL28B genotype was CC in 117 (34%), CT in 166 (49%) and TT in 52 (15%). At univariate analysis, the IL28B CC genotype was associated with severe portal inflammation in HCV-1 patients (CC vs. CT/TT: 86% vs. 63%, p = 0.005), severe lobular inflammation in HCV-2 patients (CC vs. CT/TT: 44% vs. 23%, p = 0.03), and less fatty infiltration in HCV-1 patients (CC vs. CT/TT: 72% vs. 51%, p = 0.02). Despite the lack of any association between IL28B and fibrosis stage, in HCV-3 patients IL28B CC correlated with METAVIR F3-F4 (CC vs. CT/TT: 74% vs. 26%, p = 0.05). At multivariate analysis, the genotype CC remained associated with severe portal inflammation in HCV-1, only (Odds Ratio (OR): 95% Confidence Interval (CI): 3.24 (1.23-8.51)). IL28B genotype is associated with the histological features of chronic hepatitis C in a HCV genotype dependent manner, with CC genotype being independently associated with severe portal inflammation.
Keyword Fibrosis
Hepatitis C virus (HCV)
Histology
Interleukin 28B (IL28B) polymorphism
Liver biopsy
Natural history
Necroinflammation
Steatosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Created: Thu, 18 Sep 2014, 09:21:48 EST by Anthony Yeates on behalf of School of Medicine