Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK

Liu, Ji, Lau, Eunice Yuen-Ting, Chen, Jiezhong, Yong, Joan, Tang, Kai Dun, Lo, Jessica, Ng, Irene Oi-Lin, Lee, Terence Kin-Wah and Ling, Ming-Tat (2014) Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK. BMC Complementary and Alternative Medicine, 14 1: . doi:10.1186/1472-6882-14-303


Author Liu, Ji
Lau, Eunice Yuen-Ting
Chen, Jiezhong
Yong, Joan
Tang, Kai Dun
Lo, Jessica
Ng, Irene Oi-Lin
Lee, Terence Kin-Wah
Ling, Ming-Tat
Title Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK
Journal name BMC Complementary and Alternative Medicine   Check publisher's open access policy
ISSN 1472-6882
Publication date 2014-08-16
Sub-type Article (original research)
DOI 10.1186/1472-6882-14-303
Open Access Status DOI
Volume 14
Issue 1
Total pages 6
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Language eng
Formatted abstract
Background
Prostate cancer (PCa) frequently relapses after hormone ablation therapy. Unfortunately, once progressed to the castration resistant stage, the disease is regarded as incurable as prostate cancer cells are highly resistant to conventional chemotherapy.

Method
We recently reported that the two natural compounds polysaccharopeptide (PSP) and Gamma-tocotrienols (γ-T3) possessed potent anti-cancer activities through targeting of CSCs. In the present study, using both prostate cancer cell line and xenograft models, we seek to investigate the therapeutic potential of combining γ-T3 and PSP in the treatment of prostate cancer.

Result
We showed that in the presence of PSP, γ-T3 treatment induce a drastic activation of AMP-activated protein kinase (AMPK). This was accompanied with inactivation of acetyl-CoA carboxylase (ACC), as evidenced by the increased phosphorylation levels at Ser 79. In addition, PSP treatment also sensitized cancer cells toward γ-T3-induced cytotoxicity. Furthermore, we demonstrated for the first time that combination of PSP and γ-T3 treaments significantly reduced the growth of prostate tumor in vivo.

Conclusion
Our results indicate that PSP and γ-T3 treaments may have synergistic anti-cancer effect in vitro and in vivo, which warrants further investigation as a potential combination therapy for the treatment of cancer.
Keyword Polysaccharopeptide
Tocotrienol
AMPK
Prostate cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article no.: 303

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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