Inflammation and frailty measures in older people

Hubbard, Ruth E., O'Mahony, M. Sinead, Savva, George M., Calver, Brian L. and Woodhouse, Ken W. (2009) Inflammation and frailty measures in older people. Journal of Cellular and Molecular Medicine, 13 9 B: 3103-3109. doi:10.1111/j.1582-4934.2009.00733.x

Author Hubbard, Ruth E.
O'Mahony, M. Sinead
Savva, George M.
Calver, Brian L.
Woodhouse, Ken W.
Title Inflammation and frailty measures in older people
Journal name Journal of Cellular and Molecular Medicine   Check publisher's open access policy
ISSN 1582-1838
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1582-4934.2009.00733.x
Open Access Status DOI
Volume 13
Issue 9 B
Start page 3103
End page 3109
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd
Collection year 2009
Language eng
Subject 1307 Cell Biology
1313 Molecular Medicine
Abstract Inflammation in patients defined as frail by Fried's phenotypic definition may be related to sarcopenia. This study aimed to investigate inflammation in older patients across different frailty criteria. Frailty status was determined in 110 patients aged over 75 years (mean 83.9 years) according to function (dependent, intermediate, independent); Fried (three or more items of exhaustion, weight loss, slow walking speed, low handgrip strength, low physical activity) and Frailty Index (a measure of accumulated deficits). With increasing patient frailty as defined by function and by Fried phenotype, tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) increased significantly. Albumin was lowest in the frailest subjects by each definition. The greatest differences were seen between intermediate and dependent groups and between the pre-frail and frail. Adjustment for multiple covariates (age, sex, BMI category, smoking status, number of co-morbidities and number of prescribed medications) did not account for any of the observed differences in levels of inflammatory markers. The Frailty Index correlated significantly with log-transformed CRP (r = 0.221, P < 0.05), log-transformed IL-6 (r = 0.369, P < 0.01), TNF-α (r = 0.379, P < 0.01) and inversely with albumin (r = - 0.545, P < 0.01). This study provides further evidence linking inflammation and frailty in older people, an association that seems consistent across different frailty measures. © 2009 The Authors Journal compilation
Keyword Eighty and over
C reactive protein
Frail elderly
Interleukin 6
Tumour necrosis factor alpha inhibitors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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