High-powered percutaneous microwave ablation of stage i medically inoperable non-small cell lung cancer: A preliminary study

Liu, Howard and Steinke, Karin (2013) High-powered percutaneous microwave ablation of stage i medically inoperable non-small cell lung cancer: A preliminary study. Journal of Medical Imaging and Radiation Oncology, 57 4: 466-474. doi:10.1111/1754-9485.12068

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Author Liu, Howard
Steinke, Karin
Title High-powered percutaneous microwave ablation of stage i medically inoperable non-small cell lung cancer: A preliminary study
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
1754-9485
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1111/1754-9485.12068
Open Access Status
Volume 57
Issue 4
Start page 466
End page 474
Total pages 9
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2013
Language eng
Subject 2741 Radiology Nuclear Medicine and imaging
2730 Oncology
Abstract Purpose To retrospectively evaluate the feasibility and outcome of using high-powered percutaneous microwave ablation (MWA) in treating medically inoperable early stage non-small cell lung cancer. Materials and Methods From November 2010 to June 2012, 15 patients underwent CT-guided MWA of 15 tumours in 16 sessions. One patient had a second ablation session for local tumour progression. Each tumour had a diameter of 40 mm or less (median 24 mm). Treatment outcome was evaluated using modified response evaluation criteria in solid tumours criteria based on follow-up contrast-enhanced CT studies and 18-F fluorodeoxyglucose positron emission tomography scans. Results Thirty-three ablation cycles of 15 tumours were performed in 16 sessions (2.1 per session), with a median duration of 2.5 min per ablation. Treatment was completed in all cases with no 30-day mortality. At a median follow-up period of 1 year, local progression was identified following 5/16 (31%) ablation sessions. Eleven out of 16 (69%) of MWAs had shown local treatment response, with 9/11 displaying complete response and 2/11 displaying partial response. Local progression on follow up was predominantly seen in pleural-based tumours that were greater than 30 mm in longest axial diameter (4/5 cases). The main adverse event was a pneumothorax, which occurred in 10/16 (63%) of procedures, but a chest tube was only required in 2/16 (13%) cases. Conclusion Percutaneous MWA in early stage non-small cell lung cancer is well tolerated and has promising midterm outcomes.
Keyword Ablation
Lung cancer
Lung tumour
Microwave ablation
Percutaneous
Thermal therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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