Transcranial magnetic stimulation as a tool for understanding neurophysiology in Huntington's disease: a review.

Philpott, April L., Fitzgerald, Paul B., Cummins, Tarrant D. R. and Georgiou-Karistianisa, Nellie (2013) Transcranial magnetic stimulation as a tool for understanding neurophysiology in Huntington's disease: a review.. Neuroscience And Biobehavioral Reviews, 37 8: 1420-1433. doi:10.1016/j.neubiorev.2013.05.009


Author Philpott, April L.
Fitzgerald, Paul B.
Cummins, Tarrant D. R.
Georgiou-Karistianisa, Nellie
Title Transcranial magnetic stimulation as a tool for understanding neurophysiology in Huntington's disease: a review.
Journal name Neuroscience And Biobehavioral Reviews   Check publisher's open access policy
ISSN 0149-7634
1873-7528
Publication date 2013-05
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.neubiorev.2013.05.009
Open Access Status
Volume 37
Issue 8
Start page 1420
End page 1433
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Collection year 2013
Language eng
Formatted abstract
Structural and functional magnetic resonance imaging modalities have been critical in advancing our understanding of the neuroanatomical and pathophysiological changes that emerge during the premanifest and symptomatic stages of Huntington's disease (HD). However, the relationship between underlying neuropathology and the motor, cognitive and behavioural changes associated with the disorder still remain poorly understood. Less conventional technologies, such as transcranial magnetic stimulation (TMS) and electroencephalography (EEG), provide a unique opportunity to further investigate the causal relationships between targeted neural circuits and objective neurophysiological responses together with overt behaviours. In this review, we discuss previous successful applications of TMS in other neurological disorders and its prospective use in HD. We also address the added value of multimodal TMS techniques, such as TMS–EEG, in investigating the integrity of neural networks in non-motor regions in HD. We conclude that neurophysiological outcome measures are likely to contribute towards characterising further the trajectory of decline across functional domains in HD, enhance understanding of underlying neural mechanisms, and offer new avenues for elucidating sensitive endophenotypic biomarkers of disease progression.
Keyword Huntingtons Disease
Transcranial Magnetic Stimulation
Electroencephalography
Cortical inhibition
Corticostriatal circuitry
Biomarker
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes ERA

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 11 Sep 2014, 12:22:32 EST by Debra McMurtrie on behalf of Queensland Brain Institute